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This research study is being done to investigate the effect of changing an infant's body position on how hard the baby works to breathe, the baby's oxygen level, the baby's carbon dioxide level, the baby's lung volume, the baby's lung compliance (ability of the lung to expand and fill with air), and how frequently the baby develops clinically significant events such as apnea (baby stops breathing on his own), bradycardia (low heart rate), and desaturation (low oxygen) events.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Prone positioning | Experimental |
| |
| Supine positioning | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Body positioning | Other | Body positioning of infants prone vs supine. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Peak electrical activity of the diaphragm (Edi peaks) | Height of Edi signal in uV | From enrollment in study to end of study (a total of twelve hours) |
| Minimum electrical activity of the diaphragm (Edi mins) | Lowest of Edi signal in uV | From enrollment in study to end of study (a total of twelve hours) |
| Number of apenic events | Number of times where infant ceases to breath for >5 seconds | From enrollment in study to end of study (a total of twelve hours) |
| Number of bradycardia events | Number of times where infant's heart rate drops <100bpm sustained for >5s | From enrollment in study to end of study (a total of twelve hours) |
| Number of desaturation events | Number of times where infant's oxygen saturation drops <85% sustained for >5s | From enrollment in study to end of study (a total of twelve hours) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kristin Glass, MD | Penn State College of Medicine | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Penn State Health Milton S Hershey Medical Center | Hershey | Pennsylvania | 17033 | United States |
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| ID | Term |
|---|---|
| D001238 | Asphyxia Neonatorum |
| D047928 | Premature Birth |
| D001997 | Bronchopulmonary Dysplasia |
| D001049 | Apnea |
| ID | Term |
|---|---|
| D007232 | Infant, Newborn, Diseases |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
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| ID | Term |
|---|---|
| D011187 | Posture |
| ID | Term |
|---|---|
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D055397 | Ventilator-Induced Lung Injury |
| D055370 | Lung Injury |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D007235 | Infant, Premature, Diseases |
| D012120 | Respiration Disorders |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |