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This study is to investigate the effect of a wide range of assistance levels on respiratory pattern, breathing variability including tidal volume and peak inspiratory pressure during neurally adjusted ventilatory assist (NAVA) in preterm infants. The investigators also aim to explore whether the effects of NAVA on the electrical activity of diaphragm (Edi) signal amplitude, work of breathing and comfort of preterm infants.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| NAVA | Experimental | Seven increasing and decreasing NAVA levels (0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 3.5, 3.0, 2.5, 2.0, 1.5, 1.0 and 0.5 cmH2O/uV) will applied to 20 preterm infants each for 10 minutes. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Increasing and decreasing NAVA levels with 10-min intervals | Device |
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| Measure | Description | Time Frame |
|---|---|---|
| maximum Edi | mean of recorded maximum electrical activities in the middle 2 min duration out of the total 10 min period | the middle 2 minutes duration out of the total interval of 10 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| comfort score | calculated score of premature infant pain profile (PIPP) from the recorded video, heart rates and oxygen saturation | the 5-min point in the total 10-min period |
| peak inspiratory pressure |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Inha University Hospital | Incheon | 22332 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31077579 | Derived | Nam SK, Lee J, Jun YH. Neural feedback is insufficient in preterm infants during neurally adjusted ventilatory assist. Pediatr Pulmonol. 2019 Aug;54(8):1277-1283. doi: 10.1002/ppul.24352. Epub 2019 May 11. |
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| ID | Term |
|---|---|
| C566881 | Respiratory Distress Syndrome In Premature Infants |
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mean of recorded peak inspiratory pressures in the middle 2 min duration out of the total 10 min period
| the middle 2 minutes duration out of the total interval of 10 minutes |
| tidal volume | mean of recorded expiratory tidal volumes in the middle 2 min duration out of the total 10 min period | the middle 2 minutes duration out of the total interval of 10 minutes |
| inspiratory time in excess | mean of calculated excessive inspiratory times from the calculation ((ventilator pressurization time-neural inspiratory time)/neural inspiratory time) from the middle 2 min duration out of the total 10 min period | the middle 2 minutes duration out of the total interval of 10 minutes |
| electrical time product | mean of calculated electrical time product from the middle 2 min duration out of the total 10 min period | the middle 2 minutes duration out of the total interval of 10 minutes |