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| ID | Type | Description | Link |
|---|---|---|---|
| 2023-A00049-36 | Other Identifier | ID-RCB |
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Several authors suggest that the specific experience felt in clinical encounter, called Praecox Feeling, is directly linked to the psychopathology of Schizophrenia.
However, determining factors of this phenomena, whether cognitive or subjective, remains poorly studied.
Furthermore, Self-Disorders are alterations of the first-person experience regarded as specific of the disease. The investigators plan to study in an exploratory way the phenomenological and subjective links between Praecox Feeling and Self Disorders determinants, while hypothesizing that the clinician's Praecox Feeling can be positively correlated to SDs, as our main objective.
Several authors suggest that the specific experience felt in clinical encounter, called Praecox Feeling, is directly linked to the psychopathology of Schizophrenia. However, subjective, cognitive or neurophysiologic aspects of this phenomena remains poorly studied.
Furthermore, Self-Disorders (SD) are alterations of the first-person experience and of sense of agency, regarded as specific of Schizophrenia. Unlike Praecox Feeling, clinical, cognitive and neuropsychological determinants of SD are increasingly studied.
The investigators plan to study in an exploratory way the links between Praecox Feeling and SDs determinants, while hypothesizing that the clinician's Praecox Feeling can be positively correlated to SDs, as our main objective.
As a secondary outcome, the investigators will control this correlation by a comparison between SDs evaluation and clinician subjectivity.
The present study also plan to evaluate the associations between Praecox Feeling and clinical features, low and high cognitive level with attentional and social cognition evaluations.
The first step of the research project is to implement this exploratory design in a transversal multicentric setting between centers with a limited number of participants and without follow-up.
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| Measure | Description | Time Frame |
|---|---|---|
| Correlation between Praecox Feeling and Self Disorders | Comparison between Examination of Anomalous Subjective Experience (EASE) total score evaluated at third visit and mean of Praecox Feeling intensity measured by a visual analog scale (VAS) evaluated at each visit. Examination of Anomalous Subjective Experience is a 5-item interview asked by the investigator. Visual Analog Scale (VAS) is a scale that evaluates the level of strangeness felt during the patient/investigator encounter. It goes from 0 (no strangeness feeling) to 100 (maximal strangeness feeling). | 2 months |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between Praecox Feeling and symptomatic dimensions | Comparison between mean of Praecox Feeling intensity measured by a visual analog scale evaluated at each visit and Cognition evaluation in second visit with attentional evaluation (D2-R and results at Go/No-Go testing) and social cognition evaluation (TOM-15). D2-R is a paper-and-pencil test. It's consists of the subject identifying and crossing out target characters (d with 2 lines) from a large number of characters. Go/No-Go testing is a test assesses behavioural control in a test where the participant must be able to respond to an automated external stimulus. TOM-15 consists of a false belief task and a comprehension task using the same 15 stories but different questions. The stories proposed show everyday situations. There are 8 first-order questions and 7 second-order questions, allowing two scores to be calculated, one for each order (maximum 15 in total). The more correct answers, the higher the score |
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Inclusion Criteria:
Exclusion Criteria:
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Stabilised patients with schizophrenia
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Tudi GOZE, MD | Contact | 5 61 77 23 60 | +33 | goze.t@chu-toulouse.fr |
| Name | Affiliation | Role |
|---|---|---|
| Tudi GOZE, MD | University Hospital, Toulouse | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Toulouse | Recruiting | Toulouse | France |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
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| 2 months |
| Correlation between Praecox Feeling intensity and Self Disorders intensity | Comparison between Examination of Anomalous Subjective Experience (EASE) total score a the third visit and mean of clinician subjectivity measured by Assessment of clinician's subjective experience (ACSE) at each visit. Examination of Anomalous Subjective Experience is a scale completed during the clinical interview by the investigator. It consists a 5-item scale. Assessment of clinician's subjective experience is a scale completed during the clinical interview by the investigator. It is composed of 45 items. | 2 months |
| Correlation between the patient's judgment and the quality of the meeting | Meeting Quality, according to the participant, evaluated at second visit in an unstructured way. | 2 months |