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| Name | Class |
|---|---|
| Fondation pour la Recherche Médicale | OTHER |
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The main purpose of the study is to examine to which extent abnormalities in the dynamics of neural activities observed in patients with psychosis is related to difficulties at ordering simple visual stimuli and/or personal events.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy volunteer | Experimental |
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| Patients with schizophrenia | Experimental |
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| Patient with bipolar disorder | Experimental |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fMRI | Other | Connectivity between the areas related to information processing over time and the areas activated during the rest activity. We will verify whether the activation anomalies observed during time tasks predict anomalies in spontaneous activity dynamics. |
| Measure | Description | Time Frame |
|---|---|---|
| Abnormalities in connectivity during order judgement tasks will be taken as seeds to check whether they account for abnormalities in connectivity at rest, by means of mathematic modelization | After study completion (2 years) |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of the brain' functional coupling dynamics over time (how neuronal networks and connectivity change over time) during rest. | After study completion (2 years) | |
| - Evaluation of the brain' functional coupling dynamics over time (how neuronal networks and connectivity change over time) during time ordering. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anne GIERSCH | Strasbourg's University Hospitals - INSERM 1114 Unit | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service de psychiatrie | Strasbourg | 67000 | France |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| D001714 | Bipolar Disorder |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
| D000068105 | Bipolar and Related Disorders |
| D019964 | Mood Disorders |
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| EEG | Other | link between EEG response anomalies related to information processing over time and response anomalies recorded during rest activity. We will check whether anomalies in EEG oscillatory responses during time tasks predict anomalies during the rest task. |
|
| After study completion (2 years) |
| Comparison of patients with schizophrenia vs. bipolar disorder | During fMRI and EEG sessions |