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| Name | Class |
|---|---|
| Natural Sciences and Engineering Research Council, Canada | OTHER |
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The purpose of the proposed study is to broaden our understanding on the neural effects of High Definition Transcranial Direct Current Stimulation (HD-tDCS) so that its clinical effects can be further improved.
Normal healthy individuals will be recruited and undergo a standardized neuropsychological assessment (ANAM, MoCA, BDI-II, ToMS, and MAAS) and magnetic resonance imaging (MRI). During MRI, HD-tDCS will be applied. Four different stimulation targets will be investigated, and subjects will be randomly assigned for each target groups or sham group. After HD-tDCS/MRI session, subjects will be re-assessed with standardized neuropsychological tests.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| left DLPFC stimulation | Experimental | HD-tDCS will be used to deliver direct current to the target via rubber electrodes and HD-tDCS gels. The 9 electrodes (8 channels + 1 ground) positions and current intensity will be determined based on computer simulation using HDTargets software (Soterix Inc.) that results in maximum focal current on the left dorsolateral prefrontal cortex (DLPFC; x=-44, y=10, z=30) with inward field orientation. The peak current will not exceed 2 mA. A constant current will be delivered for 20 minutes. |
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| right DLPFC stimulation | Experimental | HD-tDCS will be used to deliver direct current to the target via rubber electrodes and HD-tDCS gels. The 9 electrodes (8 channels + 1 ground) positions and current intensity will be determined based on computer simulation using HDTargets software (Soterix Inc.) that results in maximum focal current on the right dorsolateral prefrontal cortex (DLPFC; x=+42, y=+14, z=+30) with inward field orientation. The peak current will not exceed 2 mA. A constant current will be delivered for 20 minutes. |
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| left IPL stimulation | Experimental | HD-tDCS will be used to deliver direct current to the target via rubber electrodes and HD-tDCS gels. The 9 electrodes (8 channels + 1 ground) positions and current intensity will be determined based on computer simulation using HDTargets software (Soterix Inc.) that results in maximum focal current on the left intraparietal lobe (IPL; x=-50, y=-36, z=+42) with inward field orientation. The peak current will not exceed 2 mA. A constant current will be delivered for 20 minutes. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| high definition transcranial direct current stimulation (HD-tDCS) | Device | HD-tDCS will be provided for 20 minutes for each stimulation with peak intensity of 2mA. |
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| Measure | Description | Time Frame |
|---|---|---|
| change of functional connectivity | Changes in seed-based connectivity originating from the targeted brain regions immediately after the brain stimulation | 0-11 minutes after the stimulation contrasting baseline (before stimulation) |
| Measure | Description | Time Frame |
|---|---|---|
| change of cerebral blood flow | Changes in Cerebral Blood Flow (estimated using pseudo continuous arterial spin labeling ) | 12-16 minutes after the stimulation contrasting baseline (before stimulation) |
| Toronto Mindfulness Scale (curiosity) |
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Inclusion Criteria:
- All other than excluded.
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ji Hyun Ko, PhD | Contact | 2042930724 | ji.ko@umanitoba.ca |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Manitoba | Recruiting | Winnipeg | Manitoba | R3E 0J9 | Canada |
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4 active treatment groups + 1 inactive treatment group
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Randomization will happen after baseline assessment. After-intervention assessment will only consist of self-report and computerized assessment. Participants will not aware of the treatment group that they were assigned to.
| VLPFC-PCC stimulation | Experimental | HD-tDCS will be used to deliver direct current to the target via rubber electrodes and HD-tDCS gels. The 9 electrodes (8 channels + 1 ground) positions and current intensity will be determined based on computer simulation using HDTargets software (Soterix Inc.) that results in maximum focal current on the left ventrolateral prefrontal cortex (VLPFC; x=-50, y=+26, z=+8) and posterior cingulate cortex (PCC; x=1, y=-61, z=38) with inward field orientation. The peak current will not exceed 2 mA. A constant current will be delivered for 20 minutes. |
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| Sham stimulation | Sham Comparator | One of the above three targets will be randomly selected. The current will be applied for 30 seconds ramp-up followed by 30 seconds ramp-down. |
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mindfulness scale for curiosity. min: 0, max: 30. Higher score means higher curiosity-mindfulness.
| Baseline, then within 1-2 hours from stimulation |
| Toronto Mindfulness Scale (decentering) | mindfulness scale for decentering. min: 0, max: 35. Higher score means higher decentering-mindfulness. | Baseline, then within 1-2 hours from stimulation |