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The detection of adenomas is the basis for the follow-up of patients with familial adenomatous polyposis, after colectomy, with a remnant rectum or an ileal pouch. The optimal method for the adenomas detection is not defined yet. Despite the proven effectiveness of indigo-carmine in different indications dye chromoendoscopy is not used in a consensual way at the international level. The situation of the ileal pouch is specific as adenomas have a usually flat shape and are much more difficult to identify than in the situation of a remnant rectum, even in the situation of > 5 mm adenomas that should be resected.
Our hypothesis is that indigo-carmine can improve adenomas detection, including > 5 mm adenomas, in patients with a an ileal pouch after colectomy improving the effectiveness of surveillance programs and potentially reducing the risk of cancer in this population.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ileoanal pouch adenomas detection assessment | Every patient who needs follow up lower digestive examination for familial adenomatous polyposis after colectomy can join this study with ileal pouch adenomas detection by experienced endoscopist. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Adenomas detection rate with the different observation methods | Procedure | Films performed in white light high definition, NBI and indigo-carmine dye, will be compared blindly to detecte number of adenomas with the different observation methods |
| Measure | Description | Time Frame |
|---|---|---|
| Average number of ileal pouch/reservoir adenomas | Average number of ileal pouch/reservoir adenomas detected according to the endoscopic mode (staining or not, virtual or not) based on a paired review of the films with final consensus in case of discordance | 6 months after colonoscopy |
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Inclusion Criteria:
Exclusion Criteria:
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Adults with familial adenomatous polyposis after colectomy
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jean-Christophe SAURIN, Pr | Contact | +33 (0)4 72 11 75 72 | jean-christophe.saurin@chu-lyon.fr | |
| Maira MORENO, PhD | Contact | +33 (0)4 72 11 75 13 | rechercheclinique@sfed.org |
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| ID | Term |
|---|---|
| D018256 | Adenomatous Polyps |
| D011125 | Adenomatous Polyposis Coli |
| D000236 | Adenoma |
| ID | Term |
|---|---|
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D015179 | Colorectal Neoplasms |
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| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009386 | Neoplastic Syndromes, Hereditary |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D044483 | Intestinal Polyposis |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |