Influence of Sulindac and Probiotics on the Development of Pouch Adenomas in Patients With Familial Adenomatous Polyposis

Adenoma-Carcinoma Sequence in the Ileal Pouch Anal Anastomosis in Patients With Familial Adenomatous Polyposis: Studies on Luminal and Mucosal Risk Factors and Chemoprevention

The purpose of this study is to determine whether sulindac and VSL#3 - inulin, either combined or alone, are effective in treating or preventing adenoma development in the ileal anal pouch in patients with familial adenomatous polyposis.

Inclusion Criteria:

• Clinically or genetically proven familial adenomatous polyposis
• Restorative proctocolectomy with ileal pouch anal anastomosis

Exclusion Criteria:

• Chronic or acute renal or hepatic disease
• History of oesophageal, gastric or duodenal ulcers
• Known hypersensitivity to sulindac
• Daily use during the last three months of:
• Aspirin
• Non-Steroidal Anti-Inflammatory Agents
• Probiotics