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The investigators wish to test a diagnostic risk score for autoimmune encephalitis in case of encephalitis, previously validated by two American teams, in a retrospective analysis, according to the clinical and paraclinical data available in our database of the Reference Centre for Autoimmune Encephalitis and Paraneoplastic Neurological Syndromes of Professor Honnorat for patients with NMDAr, anti LGi1, anti CASPR2, anti GABAbr and anti GAD antibodies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| NMDAr patients | Patients > or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti NMDAr |
| |
| LGI1 patients | Patients > or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti LGI1 |
| |
| CASPR2 patients | Patients > or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti CASPR2 |
| |
| GABAb patients | Patients > or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti GABAb |
| |
| GAD patients | Patients > or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies : - Anti GAD |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Clinical score of Granillo and al. | Other | Compare the performance of the clinical prediction score of confirmed autoimmune encephalitis according to the type of antibody isolated from the CSF. |
| Measure | Description | Time Frame |
|---|---|---|
| Validation of a diagnostic score for encephalitis to assess the risk of autoimmune origin. | Comorbidities assessed by the Charlson score | At baseline |
| Symptoms in the acute phase | At baseline | |
| Mode of onset of disease | At baseline | |
| Results of lumbar puncture | At baseline | |
| Results of antineuronal antibodies in CSF | At baseline | |
| Results of antineuronal antibodies in serum | At baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Patients > or = 18 years old presenting with auto-immune encephalitis, defined according to the Graus criteria, with neuronal antibodies :
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre de référence des syndromes neurologiques paranéoplasiques et encéphalites auto-immunes | Lyon | France |
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| ID | Term |
|---|---|
| D020274 | Autoimmune Diseases of the Nervous System |
| ID | Term |
|---|---|
| D009422 | Nervous System Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
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