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Using a retrospective cohort of 501 patients with anti-NMDAR encephalitis to assess clinical and immunological prognostic biomarkers
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Anti-NMDAR encephalitis | Patients with well-characterized anti-NMDAR encephalitis. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Description of clinical characteristic | Other | This is a non-interventional study involving clinical data and biological samples (blood, DNA, CSF). Clinical data are collected for the center and samples are already stored in biobank repositories and collected as part of "good clinical practice" in the diagnostic process of patients with suspected autoimmune encephalitis, meaning that the standard diagnostic and therapeutic approaches will not be altered in the selected study population. Patients have already gave explicit written consent for biological specimens sampling and storage at the "Centre de Ressources Biologiques des Hospices Civils de Lyon" (CRB-HCL) (including tissue, cells or biological fluids) and genetic analysis for research purposes. Additionally, patients will be informed about the present study. |
| Measure | Description | Time Frame |
|---|---|---|
| Modified Rankin scale (mRS) | Scale for measuring the degree of dependence in the daily activities of people who have suffered of neurological disability. 0 - No symptoms.
| Baseline |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with well-characterized anti-NMDAR encephalitis
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Neurologique Pierre Wertheimer / Groupement Hospitalier Est | Lyon | BRON | 69677 | France |
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| ID | Term |
|---|---|
| D060426 | Anti-N-Methyl-D-Aspartate Receptor Encephalitis |
| D012008 | Recurrence |
| ID | Term |
|---|---|
| D020361 | Paraneoplastic Syndromes, Nervous System |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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Blood, DNA, cells, CSF collected at diagnosis time
|
| D010257 | Paraneoplastic Syndromes |
| D004660 | Encephalitis |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D019636 | Neurodegenerative Diseases |
| D000090862 | Neuroinflammatory Diseases |
| D020274 | Autoimmune Diseases of the Nervous System |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |