Pre-operative 5% Dextrose Infusion & PONV

Is Pre-operative Infusion of 5% Dextrose Effective in Reducing the Incidence of PONV in Middle Ear Surgery? A Blinded Randomized Control Trial

With this study, we aim to compare the efficacy of pre-operative dextrose-containing fluid infusion with other fluid for the prevention of PONV in middle ear surgeries.

We hypothesized that maintenance of stable level of blood glucose in addition to adequate hydration through preoperative intravenous dextrose 5% infusion will have a rule in decreasing the incidence and severity of PONV; as it reduces insulin resistance and decreases gastric acid secretion; which may contribute to PONV.

Inclusion Criteria:

• ASA physical status I and ll.
• Patients undergoing middle ear surgeries, mastoidectomy, or tympanoplasty

Exclusion Criteria:

• history of dependence or use of antiemetics
• history of motion sickness
• presence of psychiatric illness
• pregnant and lactating women
• cardiovascular disorders (Ischemic heart diseases, congestive heart failure and valvular diseases)
• Diabetic patients