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Sometimes, it is necessary to re-learn a previously learned movement behavior, for example, a bad posture during the golf drive or while playing the piano. Unlearning or relearning an intensively trained behavior is particularly important if the behavior is hampering recovery, for example, in chronic pain or after a stroke. With this pilot study, the brain mechanisms that control the change of pre-existing stable memories of a motor skill will be tested with electroencephalography (EEG). Non-invasive brain stimulation will be used to modulate these brain mechanisms and test if it is possible to change the pre-existing motor memory and the learning of a new motor skill.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active non-invasive brain stimulation during behavioral memory interference | Experimental | Non-invasive brain stimulation with transcranial alternating current stimulation will be applied during a memory interference intervention. |
|
| Sham stimulation during behavioral memory interference | Sham Comparator | Inactive (sham) stimulation will be applied during a memory interference intervention. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial alternating current stimulation (tACS) combined with behavioral intervention | Other | Transcranial alternating current stimulation (tACS) combined with behavioral intervention (memory interference). |
| Measure | Description | Time Frame |
|---|---|---|
| Behavioral: interference rate | Change in performance precision of a previously learned sensorimotor skill | before - after one single intervention (1 hour) |
| Neural: brain connectivity change | Change in EEG-derived markers of brain activation and connectivity | before - after one single intervention (1 hour) |
| Measure | Description | Time Frame |
|---|---|---|
| Behavioral: interference rate | Change in performance precision of a previously learned sensorimotor skill | before - after one single intervention (24 hour follow-up) |
| Neural: brain connectivity change |
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Inclusion Criteria:
Exclusion Criteria:
• Pregnancy
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| Name | Affiliation | Role |
|---|---|---|
| Kirstin-Friederike Heise, PhD | Medical University of South Carolina | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University of South Carolina | Charleston | South Carolina | 29425 | United States |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| D001521 | Behavior Therapy |
| C005703 | salicylhydroxamic acid |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| Inactive (sham) stimulation combined with behavioral intervention | Other | Inactive (sham) stimulation combined with behavioral intervention (memory interference) |
|
Change in EEG-derived markers of brain activation and connectivity
| before - after one single intervention (24 hour follow-up) |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |
| D011613 | Psychotherapy |