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The aim of this study is to evaluate the relationship between fibrinogen use and bleeding in patients who underwent cesarean section with a prediagnosis of PAS.
The key question(s) it aims to answer are:
[Does the use of fibrinogen concentrate reduce bleeding in PAS patients?] Patients who had a cesarean section with a pre-diagnosis of PAS were analyzed retrospectively. The choice of anesthesia applied to the patients and the relationship between the use of blood products and bleeding were evaluated.
Our study was designed as a retrospective randomized study. Patients aged 20-50 years and >34 weeks of gestation who accepted the birth with a cesarean section with a pre-diagnosis of PAS were evaluated retrospectively.
examined. were randomized into 2 groups, 53 patients in each group: group1: GNF : the group without fibrinogen concentrate
Group 2: GF: the group with fibrinogen concentrate
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| grup 1: the group without fibrinogen concentrate (GNF) | Experimental | grup 1: the group without fibrinogen concentrate (GNF) |
|
| Grup 2: the group with fibrinogen concentrate | Experimental | Grup 2: the group with fibrinogen concentrate |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| the group without fibrinogen concentrate (GNF) , the group with fibrinogen concentrate (GF) | Procedure | the group without fibrinogen concentrate (GNF, ) the group with fibrinogen concentrate (GF) |
| Measure | Description | Time Frame |
|---|---|---|
| Laboratory hemoglobin level(g/dl) | Our primary aim was to evaluate the postoperative day 1(POD 1) hemoglobin values(g/dl). | Change from preoperative to postoperative day 1(POD 1) hemoglobin values (g/dl). |
| Measure | Description | Time Frame |
|---|---|---|
| The intensive care unit (ICU) admission and length of stay. | The secondary aim was to investigate the intensive care unit (ICU) admission and length of stay. | postoperatively up to 1 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Duygu Akyol | Başakşehir Çam & Sakura City Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Duygu Akyol | Istanbul | Basaksehir | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33204176 | Background | Morlando M, Collins S. Placenta Accreta Spectrum Disorders: Challenges, Risks, and Management Strategies. Int J Womens Health. 2020 Nov 10;12:1033-1045. doi: 10.2147/IJWH.S224191. eCollection 2020. | |
| 30821559 | Background | Shainker S, Shamshirsaz A, Haviland M, O'Brien K, Redhunt A, Bateni Z, Moaddab A, Fox K, Hui SK, Belfort M, Dildy G, Hacker M. Utilization and outcomes of massive transfusion protocols in women with and without invasive placentation. J Matern Fetal Neonatal Med. 2020 Nov;33(21):3614-3618. doi: 10.1080/14767058.2019.1581168. Epub 2019 Mar 1. |
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| ID | Term |
|---|---|
| D010921 | Placenta Accreta |
| D006473 | Postpartum Hemorrhage |
| ID | Term |
|---|---|
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D005340 | Fibrinogen |
| ID | Term |
|---|---|
| D000209 | Acute-Phase Proteins |
| D001798 | Blood Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
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retrospective randomized study
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retrospective randomized study
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|
| 30025661 | Result | DeSimone RA, Leung WK, Schwartz J. Transfusion Medicine in a Multidisciplinary Approach to Morbidly Adherent Placenta: Preparing for and Preventing the Worst. Transfus Med Rev. 2018 Oct;32(4):244-248. doi: 10.1016/j.tmrv.2018.05.007. Epub 2018 Jun 27. |
| D010922 | Placenta Diseases |
| D011644 | Puerperal Disorders |
| D014592 | Uterine Hemorrhage |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001779 |
| Blood Coagulation Factors |
| D011498 | Protein Precursors |
| D001685 | Biological Factors |