Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation

Neurophysiology Biomarkers of Cognitive Impairment Associated With Deep Brain Stimulation

The study aims to investigate cognitive impairment associated with Deep Brain Stimulation (DBS) in Parkinson's Disease patients, with a focus on identifying neurophysiology biomarkers of DBS associated cognitive changes. Using neurophysiology data recorded during DBS surgeries and post-implantation, the research intends to identify biomarkers in order to optimize electrode placement, enhance programming, and ultimately minimize DBS-related cognitive side effects.

Inclusion Criteria:

• Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center (Arm 1)

• Active deep brain stimulation system with implantable pulse generator capable of recording local field potentials (Arm 2)
• Diagnosis of Parkinson's disease as determined by a movement disorders specialist neurologist
• Age at least 18
• Able to participate in intraoperative testing
• English speaking

Exclusion Criteria:

• Age less than 18
• Not able to participate in intraoperative testing (ex unable to comprehend instructions or follow directions)