Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment

Corticostriatal Neurophysiology in Parkinson's Disease Cognitive Impairment

The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.

Inclusion criteria:

• Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center
• Planned clinical electrode trajectory that contacts caudate
• Age greater than or equal to 40
• Diagnosis of Parkinson's disease
• Able to participate in intraoperative testing
• English speaking

Exclusion criteria:

• Age less than 40
• Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions)
• Movement disorder other than Parkinson's disease