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The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Neural recordings and stimulation | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Neurophysiology recordings | Other | Neurophysiology recordings will be performed during deep brain stimulation surgery and their relationship to performance on a gambling task evaluated |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in caudate DLPFC beta coherence | Caudate DLPFC coherence will be computed at rest and during the gambling task and correlated with cognitive metrics | Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours |
| Changes in gambling task performance with neural stimulation | The gambling task will involve seeing a series of cards presented on the screen and pressing a button to respond with a bet. Gambling task performance will be compared between stimulated and non stimulated blocks and between stimulation targets | Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Change in beta power with neural stimulation | Beta power will be computed and compared between stimulation on and off conditions for different targets | Baseline to end of deep brain stimulation (DBS) surgery, approximately 3-4 hours |
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Inclusion criteria:
Exclusion criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lucas Chang, BA | Contact | 615-421-3046 | lucas.m.chang@vumc.org | |
| Sarah Bick, MD | Contact | 615-343-9822 | Sarah.Bick@vumc.org |
| Name | Affiliation | Role |
|---|---|---|
| Sarah Bick, MD | Vanderbilt University Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Vanderbilt University Medical Center | Recruiting | Nashville | Tennessee | 37212 | United States |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| Neural stimulation | Other | Neural stimulation will be delivered during a gambling task and its impact on task performance quantified |
|
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |