Effect of Different E-cigarette Cooling Flavors on Adults' Sensory Experience TCORS 3.0

Examine the Effects of Novel E-cigarette Constituents and Determining Appropriate Concentrations Among Adults

This pilot sensory experiment will examine cooling from comparable concentrations of WS-3 and menthol to determine appropriate concentrations to use in the main study.

This pilot study will establish low and high concentrations of both WS-3 and menthol concentrations to test in the main study. An anticipated 30 adult e-cigarette users will participate in one laboratory session during which participants will be exposed to e-liquids containing five different concentrations of two different cooling flavors without nicotine (10 e-liquids total). Participants will rate "coolness" using the generalized Labeled Magnitude Scale (gLMS). Using averages of participant ratings, we will select a low concentration of each constituent that is rated as more than "barely detectable" but less than "moderate" to ensure that cooling is weak but clearly perceptible. For the high concentration of each constituent, we will select a concentration that on average falls between "strong" and "very strong" to identify a strong cooling sensation while avoiding sensations that would also be uncomfortable.

Inclusion Criteria:

• 18 years or older
• Able to read and write
• Used e-cigarettes containing nicotine
• Use e-cigs in past 30 days
• No strong dislike of the menthol flavor
• Urine cotinine ≥200ng/ml
• Willing to abstain from tobacco/nicotine use 2 hrs prior to sessions

Exclusion Criteria:

• Known hypersensitivity to propylene glycol
• Pregnant or lactating females
• Uncontrolled asthma
• Nut/e-liquid flavorant allergy
• Current marijuana (tetrahydrocannabinol) vaping + E-cigarette or vaping use Associated Lung Injury (EVALI) symptoms
• Dislike of menthol flavor