Cranberry Flavan-3-ols Consumption and Gut Microbiota in Healthy Adults

Evaluation of the Inter-individual Variability Associated With the Interaction Between Flavan-3-ols From Cranberry and Gut Microbiota - an Exploratory Study

Consumption of (poly)phenols is recognized to have beneficial effects on health. However, heterogeneous results are obtained in clinical trials due to high inter-individual variability. The objective of this pilot study is to characterize the inter-individual variability associated with the interaction of (poly)phenols from cranberry and gut microbiota.

The participants (n=39) of this study are healthy adults aged between 23 and 63 years old and consumed cranberry extract rich in (poly)phenols for 4 days. Plasma, urine and feces were collected to quantify gut microbial (poly)phenols metabolites and to profile the fecal microbiota.

Inclusion Criteria:

• Stable weight
• Stable or no medication
• Stable diet
• Stable physical activity

Exclusion Criteria:

• Pregnant women
• Antibiotic and/or probiotic use three months prior to the study
• Smokers