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In this study, the investigator aim was to compare Cathepsin B and Pentraxin 3 levels measured from maternal serum of pregnant women diagnosed with preeclampsia in the second trimester, the effects of these levels on maternal/ fetal outcomes and the composite results of Cathepsin B and Pentraxin 3 levels alone or together and contribute to the literature in this area.
This prospective case-control study was conducted between 1 January 2022 and 31 December 2022 at Bursa Yuksek Ihtisas Training and Research Hospital. The study was conducted with pregnant women between ages of 18-45 who were diagnosed with preeclampsia in the second trimester. This study was conducted with total 156 pregnant women. participants were grouped according to the presence of preeclampsia; Group1: Patients diagnosed with preeclampsia between 20-28 weeks (study group) (n:78) , Group 2: Healthy pregnant women between 20-28 weeks without a diagnosis of preeclampsia ( control group) (n:78) . As soon as preeclampsia is diagnosed and before any treatment was started, maternal serum samples were collected in the Cathepsin B and Pentraxin 3 kit in amounts suitable for the study. The samples obtained were kept in biochemistry laboratory at -80 degrees until the study was conducted. After all samples were collected, Cathepsin B and Pentraxin 3 values were measured by ELISA method.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pregnant women with preeclampsia between 20-28 weeks (study group) | Maternal serum cathepsin B and pentraxin 3 levels in 20-28 weeks pregnant women with preeclampsia |
| |
| Healthy pregnant women between 20-28 weeks ( control group) | Maternal serum cathepsin B and pentraxin 3 levels in 20-28 weeks healthy pregnant women ( control group) |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cathepsin B and pentraxin 3 levels in preeclampsia with pregnant women | Other | The effect of cathepsin b and pentraxin 3 levels on maternal/fetal outcomes in pregnant women diagnosed with preeclampsia |
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of the effects and composite results of cathepsin b and pentraxin 3 levels in pregnant women diagnosed with preeclampsia | serum cathepsin b (nmoL pNA/mL) and serum pentraxin 3 (ng/ml) levels composite results on pregnant women diagnosed with preeclampsia | 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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singleton pregnancy white people socio-cultural differences were not considered
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nefise Nazlı YENIGUL | Bursa | 16110 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D011225 | Pre-Eclampsia |
| ID | Term |
|---|---|
| D046110 | Hypertension, Pregnancy-Induced |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D002401 | Cathepsin B |
| ID | Term |
|---|---|
| D002403 | Cathepsins |
| D010447 | Peptide Hydrolases |
| D006867 | Hydrolases |
| D004798 | Enzymes |
| D045762 |
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| Enzymes and Coenzymes |
| D003546 | Cysteine Endopeptidases |
| D057056 | Cysteine Proteases |
| D010450 | Endopeptidases |