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The purpose of this study is to understand if training Parkinson's disease patients in classical guitar will improve motor function, mood, and quality of life. While medication has been found to be effective for many Parkinson's disease patients, many patients still have symptoms. Previous studies have found that music and rhythm-based activities can help Parkinson's disease symptoms. A previous study looked at the effect of playing classical guitar on Parkinson's disease symptoms. They found positive changes in Parkinson's disease symptoms that lasted for 6 weeks after the study ended. Further, there were positive changes in depression, anxiety, and quality of life.
Subjects will be asked to take part in classical guitar lessons once a week for six weeks and physical therapy once a week for six weeks. There will be 40 people enrolled in the study. Twenty people will have classical guitar lessons first and physical therapy second. The other twenty people will have physical therapy first and classical guitar lessons second. The study will last a total of 12 weeks. Each session will last 1-2 hours. Sessions will be held at the Northwest Chapter headquarters of the American Parkinson's Disease Association.
Examples of the types of activities subjects will do during the physical therapy sessions include finger exercises, tasks with both hands, tasks while standing, and tasks while walking.
Examples of the types of activities you will do during the classical guitar lessons include playing chords and songs on the guitar.
Subjects will have physical exams and complete questionnaires at the beginning of the study, at six weeks, and at the end of the study.
If subjects have Apple watches, they will be asked to download an application called StrivePD on their watch and iPhone. StrivePD is an application that allows subjects to keep track of their Parkinson's disease symptoms or set medication reminders, for example. When used with an Apple watch, it can automatically record symptoms like tremors. During this study, the StrivePD application will only be used to collect data about what percentage of the day they have tremors and how much they sleep.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Guitar then physical therapy | Active Comparator | Subjects will learn classical guitar then have physical therapy sessions. |
|
| Physical therapy then guitar | Active Comparator | Subjects will have physical therapy sessions then learn classical guitar |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Guitar then physical therapy | Other | See arm/group descriptions |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Change in the motor subscore of the Movement Disorder Society Unified Parkinson's Disease Rating Scale Motor Subscale | Change in Parkinson's disease rating scale, range 0-32, higher score means more severe Parkinson's disease symptoms | Baseline, 6 weeks, 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Parkinson's disease Questionnaire-39 | Change in scale for quality of life, range 0-100, higher means worse Parkinson's disease symptoms | Baseline, 6 weeks, 12 weeks |
| Change in percent of day with tremor |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Christopher Adams, MS, MD | Contact | 206-616-5207 | caadams1@uw.edu |
| Name | Affiliation | Role |
|---|---|---|
| Christopher Adams, MS, MD | University of Washington | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Northwest Chapter of the American Parkinson Disease Association | Recruiting | Seattle | Washington | 98109 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40143890 | Derived | Adams C, Fulton G. A Cross-over Pilot Study on the Effects of Classical Guitar Instruction on Motor and Non-Motor Symptoms in People with Parkinson's Disease. Neurosci Insights. 2025 Mar 24;20:26331055251329878. doi: 10.1177/26331055251329878. eCollection 2025. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Mar 27, 2025 | |
| Reset | Apr 15, 2025 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Mar 27, 2025 | Apr 15, 2025 |
| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| Physical therapy then guitar |
| Other |
See arm/group descriptions |
|
Change in percent of day with tremor from apple watch
| Baseline, 6 weeks, 12 weeks |
| Change in Beck Depression Inventory-II | depression scale, range 0-63, higher score means worse depression | Baseline, 6 weeks, 12 weeks |
| Change in Apathy evaluation scale total score | Change in apathy scale, range 18-72, higher scores means worse apathy | Baseline, 6 weeks, 12 weeks |
| Change in American Parkinson's disease Association symptom tracker score | Change in Parkinson's disease symptom tracker, range 0-50, higher scores means worse symptoms | Baseline, 6 weeks, 12 weeks |
| Change in hours of sleep | Change in hours of sleep measured from apple watch data | Baseline, 6 weeks, 12 weeks |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |