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| ID | Type | Description | Link |
|---|---|---|---|
| R01DA033854 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| New York University | OTHER |
| Northwestern University | OTHER |
| University of California, San Francisco | OTHER |
| National Institute on Drug Abuse (NIDA) |
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This study will leverage extracted leukocyte DNA specimens from a completed NIH-funded project to examine the efficacy of a behavioral intervention model that reduced stimulant use on DNA methylation over 6 months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Leukocyte DNA Samples | Leukocyte DNA specimens extracted from participants enrolled in a completed NIH funded trial will be examined to determine if prior exposure to different behavioral interventions modifies DNA methylation patterns over 6 months. |
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| Measure | Description | Time Frame |
|---|---|---|
| Neuroimmune Signaling | Decreased methylation of genes for genes relevant to neuroimmune signaling such as beta-2 (β2) adrenergic (i.e., ADRB2), glucocorticoid (i.e., NR3C1 and FKBP5), and oxytocin (i.e., OXTR) receptors as well as brain-derived neurotrophic factor (BDNF) promoters. | 6 Months |
| Measure | Description | Time Frame |
|---|---|---|
| DNA Methylation Pathways | Pathway Analyses examining alterations in methylation patterns relevant to immune and neural function. | 6 Months |
| Immune Dysfunction | Soluble makers of monocyte activation such as soluble CD14 (sCD14) and inflammation such as soluble Tumor Necrosis Factor - Alpha Receptors I and II (sTNF-aRI and sTNF-aRII) |
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Inclusion Criteria:
Exclusion Criteria:
Sexual Minority Men - gay, bisexual, and other men who have sex with men.
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Sexual minority men with HIV who use methamphetamine residing in the San Francisco Bay Area.
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| Name | Affiliation | Role |
|---|---|---|
| Adam W Carrico, PhD | Florida International University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Florida International University | Miami | Florida | 33199 | United States |
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| ID | Term |
|---|---|
| D015658 | HIV Infections |
| ID | Term |
|---|---|
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D015229 | Sexually Transmitted Diseases, Viral |
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| NIH |
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| 6 Month |
| Dysregulated Metabolism of Amino Acid Precursors for Neurotransmitters measured via high-performance liquid chromatography (HPLC) | Using HPLC, higher kynurenine/tryptophan (K/T) ratio indexes catabolism of tryptophan into kynurenine and other downstream catabolites versus serotonin over 6 months. Using HPLC, the phenylalanine/tyrosine ratio reflects decreased metabolism of tyrosine into catecholamines such as dopamine over 6 months. | 6 Months |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |