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Current research and theories have highlighted that the parameters linked to movement planning, e.g. the decision to select a movement goal, and adaptation, e.g. the ability to update control dependent on a novel dynamical context, are update quickly and within an ongoing movement in the general population. In parallel, it has been suggested that the evaluation of movement costs is a function of the basal ganglia, and it is impaired in Parkinson disease (PD). Here the investigators want to test whether these mechanisms also alter the ability of patients to update control during an ongoing action. A positive result would confirm that movement-related costs and dynamical representations depend on the integrity of the basal ganglia, in contrast a negative result would indicate that the deficit in PD is more specifically related to movement initiation, which would invite one to reconsider the cause of bradykinesia in this population.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PD | Patients with Parkinson disease |
| |
| Control | Healthy volunteers |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Reaching movements | Other | Participants will be instructed to perform reaching movements by moving the handle of a robotic arm mounted with a virtual reality display. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Kinematics | Position of the handle as a function of time. Units are millimetres | Measured during the entire experiment (an average of 4.5 years) |
| Surface Electromyogram | Surface recordings of muscles activities from the main muscles involved in movement production. Units are volts | Measured during the entire experiment (an average of 4.5 years) |
| Applied forces | Forces applied by participants on the robotic handle. Units are Newtons | Measured during the entire experiment (an average of 4.5 years) |
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Inclusion Criteria:
Exclusion Criteria:
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The study will be based on two populations: on population of volunteers with Parkinson disease, and one population of age and sex matched healthy individuals.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| André Mouraux, PhD | Contact | +32 2 764 54 47 | andre.mouraux@uclouvain.be | |
| Frédéric Crevecoeur, PhD | Contact | frederic.crevecoeur@uclouvain.be |
| Name | Affiliation | Role |
|---|---|---|
| Frédéric Crevecoeur, PhD | Université Catholique de Louvain | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Université catholique de Louvain | Recruiting | Louvain-la-Neuve | 1348 | Belgium |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| Disease Assessment | Other | Disease stage assessed by trained professionals |
|
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |