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PURPOSE:
The purpose of the study is to evaluate the effect of (LLLT) on donor site wound healing following skin graft surgery.
BACKGROUND:
The skin graft is a beneficial reconstructive technique for accelerating wound healing .Managing donor site after graft harvesting is very important, and often, patients have more discomfort at the donor site than the recipient burn site itself.Using techniques that accelerate wound healing may enhance patient satisfaction.
Low-level laser therapy (LLLT) has been used in several medical fields, including healing of diabetic, surgical, and pressure ulcers.
Accelerating the healing process and reducing pain during healing are beneficial for the following reasons: faster return to work, lower risk of wound infection, improved quality of life, and possibly reduced need for analgesia.
HYPOTHESES:
It is hypothesized that:
Low level laser therapy has a positive effect on donor site wound healing following skin graft surgery in burned patients.
RESEARCH QUESTION:
Is low level laser therapy has a positive effect on donor site healing following skin graft surgery in burned patients?
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| laser group | Experimental | active low level laser therapy and conventional medical treatment. |
|
| placebo group | Placebo Comparator | placebo laser and conventional medical treatment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| low level laser therapy | Device | They recieved LLLT 1 session daily, 3 session per week for 3 weeks,with the following parameters( 650 nm wavelength, 150 mw power output, 0.25 cm2 radiation area, 0.6 W/cm2 power density, continuous mode, 2 j/ cm2, 90 seconds / cm2) in addition to the conventional medical treatment and traditional wound care (dressing) |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of wound surface area at day 1 post-operative (pre-treatment)(baseline measurement) | Measurement of wound surface area by photography and image J software at day 1 | 1 day |
| Measurement of wound surface area at day 11 post-operative (post-treatment) | Measurement of wound surface area by photography and image J software at day 11 | 11 day |
| Measurement of wound surface area at day 21 post-operative (post-treatment) | Measurement of wound surface area by photography and image J software at day 21 | 21 day |
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Inclusion Criteria:
Exclusion Criteria:
• Patients with associated diseases (Diabetes mellitus, infectious diseases, autoimmune disease) that will interfere with the healing process.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cairo University | Giza | 12613 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29368069 | Background | Vaghardoost R, Momeni M, Kazemikhoo N, Mokmeli S, Dahmardehei M, Ansari F, Nilforoushzadeh MA, Sabr Joo P, Mey Abadi S, Naderi Gharagheshlagh S, Sassani S. Effect of low-level laser therapy on the healing process of donor site in patients with grade 3 burn ulcer after skin graft surgery (a randomized clinical trial). Lasers Med Sci. 2018 Apr;33(3):603-607. doi: 10.1007/s10103-017-2430-4. Epub 2018 Jan 24. | |
| 23001637 |
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| ID | Term |
|---|---|
| D028022 | Low-Level Light Therapy |
| ID | Term |
|---|---|
| D053685 | Laser Therapy |
| D013812 | Therapeutics |
| D010789 | Phototherapy |
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|
| placebo | Behavioral | They received placebo laser 1 session daily, 3 session per week for 3 weeks in addition to the conventional medical treatment and traditional wound care (dressing) |
|
| Background |
| Assis L, Moretti AI, Abrahao TB, Cury V, Souza HP, Hamblin MR, Parizotto NA. Low-level laser therapy (808 nm) reduces inflammatory response and oxidative stress in rat tibialis anterior muscle after cryolesion. Lasers Surg Med. 2012 Nov;44(9):726-35. doi: 10.1002/lsm.22077. Epub 2012 Sep 21. |
| 33751853 | Background | Huang J, Chen J, Xiong S, Huang J, Liu Z. The effect of low-level laser therapy on diabetic foot ulcers: A meta-analysis of randomised controlled trials. Int Wound J. 2021 Dec;18(6):763-776. doi: 10.1111/iwj.13577. Epub 2021 Mar 9. |
| 19568092 | Background | Voineskos SH, Ayeni OA, McKnight L, Thoma A. Systematic review of skin graft donor-site dressings. Plast Reconstr Surg. 2009 Jul;124(1):298-306. doi: 10.1097/PRS.0b013e3181a8072f. |