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The aim of this randomized split-mouth design clinical trial is to clinically evaluate the effectiveness of diode laser in the healing of donor site of palate in free gingival graft.
Free gingival graft is the most predictable and successful method for increasing the width of keratinized tissue around teeth/dental implants and vestibular deepening. However, patient discomfort during the healing time is a major disadvantage of this procedure. Several methods have been introduced to accelerate the healing time and reduction of patient's pain during first days after surgery. Low-level lasers have shown promising results in biostimulation of cell growth and differentiation in cultures. However, there are lack of well designed double blind placebo controlled randomized controlled clinical studies evaluating the effects of Low-level laser therapy in acceleration of wound healing and pain relief of patients undergoing free gingival grafts.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| low-level laser therapy | Experimental | Low-level laser (Diode, 66o nanometer, power:200 milli Watt (mW), Continuous wave, time of irradiation:32 seconds)is irradiated in donor site |
|
| Turned-off laser | Placebo Comparator | The same protocol is applied in te donor site, unless the laser is remained off. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Low-level laser therapy | Radiation | Low-level laser therapy with the following parameters: Wavelength:660 nanometer, power: 200 mW, continuous mode, tme of irradiation: 32 seconds |
| Measure | Description | Time Frame |
|---|---|---|
| degree of epithelialization | 3% hydrogen peroxide (H2O2) was applied to the wound by a sterile gause to see the bubbling
| At day 7 |
| degree of epithelialization | 3% hydrogen peroxide (H2O2) was applied to the wound by a sterile gause to see the bubbling
| At day 14 |
| degree of epithelialization | 3% hydrogen peroxide (H2O2) was applied to the wound by a sterile gause to see the bubbling
| At day 21 |
| Measure | Description | Time Frame |
|---|---|---|
| Visual analogue scale (VAS) pain score | ask from patient about numbers of tablet consumption,record VAS analysis | at day 1 |
| Visual analogue scale (VAS) pain score | ask from patient about numbers of tablet consumption,record VAS analysis |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Neda Moslemi | Laser Research Center of Dentistry, Tehran University of Medical Sciences | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Neda Moslemi | Tehran | Tehran Province | Iran |
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| ID | Term |
|---|---|
| D005889 | Gingival Recession |
| ID | Term |
|---|---|
| D005882 | Gingival Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D028022 | Low-Level Light Therapy |
| ID | Term |
|---|---|
| D053685 | Laser Therapy |
| D013812 | Therapeutics |
| D010789 | Phototherapy |
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|
| Turned-off laser | Radiation | Laser device is turned-off. All parameters are like experimental group, however the laser in turned-off. |
|
|
| at day 2 |
| Visual analogue scale (VAS) pain score | ask from patient about numbers of tablet consumption,record VAS analysis | at day 3 |
| Visual analogue scale (VAS) pain score | ask from patient about numbers of tablet consumption,record VAS analysis | at day 4 |
| Visual analogue scale (VAS) pain score | ask from patient about numbers of tablet consumption,record VAS analysis | at day 5 |
| Visual analogue scale (VAS) pain score | ask from patient about numbers of tablet consumption,record VAS analysis | at day 6 |
| Visual analogue scale (VAS) pain score | ask from patient about numbers of tablet consumption,record VAS analysis | at day 7 |
| Visual analogue scale (VAS) pain score | ask from patient about numbers of tablet consumption,record VAS analysis | at day 14 |
| Clinical healing | Photographs were taken from donor and recipient sites. Three expert blinded periodontist photographs photographs based on shade,morphology and texture at two sessions by 48 hours interval. | at day 1 |
| Clinical healing | Photographs were taken from donor and recipient sites. Three expert blinded periodontist photographs photographs based on shade,morphology and texture at two sessions by 48 hours interval. | at day 2 |
| Clinical healing | Photographs were taken from donor and recipient sites. Three expert blinded periodontist photographs photographs based on shade,morphology and texture at two sessions by 48 hours interval. | at day 7 |
| Clinical healing | Photographs were taken from donor and recipient sites. Three expert blinded periodontist photographs photographs based on shade,morphology and texture at two sessions by 48 hours interval. | at day 14 |
| Clinical healing | Photographs were taken from donor and recipient sites. Three expert blinded periodontist photographs photographs based on shade,morphology and texture at two sessions by 48 hours interval. | at day 21 |
| D055093 |
| Periodontal Atrophy |