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The T-ICE study is a prospective, observational study aiming to have information about the treatment and long-term prognosis of patients with isolated coronary artery ectasia.
Coronary artery ectasia is a localized or diffuse enlargement of the coronary artery lumen ≥1.5-2 times relative to the normal segment. It is often associated with coronary artery stenosis. Some patients have coronary artery ectasia without stenosis. This condition is called as isolated coronary artery ectasia. There is data other than retrospective studies with a small number of cases on the clinical significance, prognosis and treatment of isolated coronary ectasia in patients with or without acute coronary syndrome. Therefore, the treatment of patients with isolated coronary ectasia is not evidence-based and is based on the clinical judgment of physicians. The aim of this prospective observational study is to evaluate the treatment and prognosis of the isolated coronary artery ectasia. The second aim is to compare the prognosis of isolated coronary ectasia with the coronary artery disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Isolated coronary ectasia | Includes the patients with isolated coronary artery ectasia without coronary stenosis. | ||
| Coronary artery disease | Includes the patients with ≥50% stenosis in a vessel ≥2 mm in diameter. |
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| Measure | Description | Time Frame |
|---|---|---|
| Major adverse cardiovascular and cerebrovascular events | A composite endpoint of death, myocardial infarction, unstable angina, stroke, and coronary revascularization. | Five years |
| Measure | Description | Time Frame |
|---|---|---|
| Major adverse cardiovascular events | A composite endpoint of cardiovascular death, myocardial infarction, unstable angina, and coronary revascularization. | Five years |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with "isolated" coronary ectasia in at least one coronary artery in their first coronary angiography performed for any reason will be included in the study.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Adnan Abaci | Contact | +903122025631 | abaci@gazi.edu.tr | |
| Emrullah Kızıltunc | Contact | +903122025629 | e.kiziltunc@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Adnan Abaci | Gazi University, School of Medicine, Department of Cardiology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gazi University, School of Medicine | Recruiting | Ankara | 06550 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16415301 | Background | Manginas A, Cokkinos DV. Coronary artery ectasias: imaging, functional assessment and clinical implications. Eur Heart J. 2006 May;27(9):1026-31. doi: 10.1093/eurheartj/ehi725. Epub 2006 Jan 16. | |
| 15194034 | Background | Baman TS, Cole JH, Devireddy CM, Sperling LS. Risk factors and outcomes in patients with coronary artery aneurysms. Am J Cardiol. 2004 Jun 15;93(12):1549-51. doi: 10.1016/j.amjcard.2004.03.011. |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| 29054186 | Background | Malviya A, Jha PK, Mishra A. Isolated coronary artery ectasia: Clinical, angiographic, and follow up characteristics. Indian Heart J. 2017 Sep-Oct;69(5):619-623. doi: 10.1016/j.ihj.2016.12.017. Epub 2017 Jan 22. |
| 20395236 | Background | Erden I, Erden EC, Ozhan H, Karabulut A, Ordu S, Yazici M. Outcome of primary percutaneous intervention in patients with infarct-related coronary artery ectasia. Angiology. 2010 Aug;61(6):574-9. doi: 10.1177/0003319709361197. Epub 2010 Apr 14. |
| 28648421 | Background | Vasu N, Narayanan S, Ajit MS. Clinical outcome of various management strategies in coronary artery ectasia. Indian Heart J. 2017 May-Jun;69(3):319-321. doi: 10.1016/j.ihj.2017.04.013. Epub 2017 May 4. No abstract available. |
| 24673382 | Background | Boles U, Zhao Y, Rakhit R, Shiu MF, Papachristidis A, David S, Koganti S, Gilbert T, Henein MY. Patterns of coronary artery ectasia and short-term outcome in acute myocardial infarction. Scand Cardiovasc J. 2014 Jun;48(3):161-6. doi: 10.3109/14017431.2014.902495. Epub 2014 Apr 10. |
| 32515749 | Background | Willner NA, Ehrenberg S, Musallam A, Roguin A. Coronary artery ectasia: prevalence, angiographic characteristics and clinical outcome. Open Heart. 2020 Apr;7(1):e001096. doi: 10.1136/openhrt-2019-001096. |
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |