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Herein, investigated the effects of 4 weeks of H2 gas inhalation on community-dwelling adults of various ages.
Molecular hydrogen (H2) is a versatile therapeutic agent. H2 gas inhalation is reportedly safe and has a positive impact on a range of illnesses, including Alzheimer's disease (AD). Herein, investigated the effects of 4 weeks of H2 gas inhalation on community-dwelling adults of various ages. Fifty-four participants including those dropped out (5%) were screened and enrolled. The selected participants were treated as a single group without randomization. Evaluated the association between total and differential white blood cell (WBC) counts and AD risk at individual levels after 4 weeks of H2 gas inhalation treatment. Furthermore, evaluation of dementia-related biomarkers such as beta-site APP cleaving enzyme 1 (BACE-1), amyloid beta (Aβ), brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor A (VEGF-A), T-tau, monocyte chemotactic protein-1 (MCP-1), and inflammatory cytokines (interleukin-6).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Single arm | Experimental | Single group treatment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| H2 gas inhalation | Other | H2 gas inhalation treatment for 4 weeks in on community dwelling adults of various ages |
|
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of white blood cell and its differential counts such as neutrophils (%), basophils (%) | 4 weeks treatment of H2 gas inhalation in community dwelling adults of various ages | 4 weeks |
| Measurement of oxidative stress markers such as reactive oxygen species (µM), and nitric oxide (µM) | 4 weeks treatment of H2 gas inhalation in community dwelling adults of various ages | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of dementia biomarkers such as brain-derived neurotrophic factor (BDNF ng/mL) | 4 weeks treatment of H2 gas treatment | 4 weeks |
| Measurement of dementia biomarkers such as brain-derived neurotrophic factor amyloid beta (Aβ (pg/mL)) |
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Inclusion
Exclusion Criteria
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| Name | Affiliation | Role |
|---|---|---|
| Prof. Kyu Jae Lee, Ph.D. | Wonju College of Medicine | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Wonju College of Medicine | Wŏnju | Ganwon-do | 26426 | South Korea | ||
| Wonju Severance Christian Hospital |
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| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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Single Group Assignment
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Before and after of treatment in single group
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4 weeks treatment of H2 gas treatment
| 4 weeks |
| Measurement of inflammatory markers such as interleukin 6 (pg/mL) | 4 weeks treatment of H2 gas treatment | 4 weeks |
| Wŏnju |
| Gwando |
| 26426 |
| South Korea |
| D024801 |
| Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |