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"Social brain" refers to brain regions dedicated to processing social information and enabling us to recognize and evaluate others' mental states. The social brain hypothesis suggests that our brains evolve to navigate complex social systems. The social brain is hypothesized to consist of a distributed network including the posterior superior temporal sulcus (pSTS), the dorsal and ventral medial prefrontal cortices (dmPFC and vmPFC), ACC and posterior cingulate cortex (PCC), the amygdala, the orbital frontal cortex (OFC), and the fusiform gyrus (FG), TPJ, inferior occipital gyrus (IOG), and the insula. Each region serves distinct role while works together to support social processing, including perceiving, interpreting, and generating responses to the intentions, dispositions, and behaviors of others.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ASD group | Experimental | autistic adolescents with their caregiver |
|
| Control group | Sham Comparator | healthy control without their caregiver |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PEERS | Behavioral | The Program for the Education and Enrichment of Relational Skills (PEERS®) studies is an evidence-based 16-week group-based social skill training program developed for adolescents and young adults with ASD. |
| Measure | Description | Time Frame |
|---|---|---|
| Autism Diagnostic Interview Revised, ADIR | Interview of the caregivers that covers most developmental and behavioral aspects of ASD. Range from 0 to 8, higher the score, worse the symptom. | 16 weeks |
| The Autism Diagnostic Observation Schedule, ADOS | Diagnosing and assess autism. Range from 0 to 8, higher the score, worse the symptom. | 16 weeks |
| Autism Spectrum Quotient | 50 items, total score range from 0 to 50. Higher the score, worse the symptom | 16 weeks |
| Social Responsiveness Scale, Second Edition (SRS-2) | 65 items, total score range from 65 to 260. Higher the score, worse the symptom | 16 weeks |
| Quality of Socialization Questionnaire (QSQ) | 12 items, total score range from 0 to 12.Higher the score, better the frequency and quality of socialization | 16 weeks |
| The Empathy Quotient (EQ) | 40 items, total score range from 0 to 80. Higher the score, worse the empathy | 16 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yi-Ling Chien, MD, PhD | Contact | +886223123456 | 66013 | chienyiling@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Taiwan University Hospital | Recruiting | Taipei | Zhongzheng Dist. | 100229 | Taiwan |
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| ID | Term |
|---|---|
| D000067877 | Autism Spectrum Disorder |
| ID | Term |
|---|---|
| D002659 | Child Development Disorders, Pervasive |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
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40 autistic adolescents are recruited with their care givers. Also, 40 healthy controls.
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