Methylene Blue Mouthwash for the Treatment of Oral Mucositis Pain in Patients With Cancer

Methylene Blue Mouthwash for Oral Mucositis Pain in Cancer: An Open-Label, Non-Randomized, Controlled Study

This phase III trial compares the effect of methylene blue mouthwash to standard of care mouthwash for the treatment of oral mucositis pain in patients with cancer. Using methlylene blue mouthwash may improve oral pain in patients with oral mucositis related to cancer and/or cancer treatments compared to usual standard of care.

Inclusion Criteria:

• Active cancer diagnosis
• Admitted to the inpatient setting
• Pain related to oral mucositis
• Experiencing oropharyngeal pain
• Able to provide informed consent

Exclusion Criteria:

• Pediatric age (under 18 years old)
• Pregnant or nursing women
• Any contraindication to methylene blue including severe hypersensitivity to methylene blue and patients with glucose-6-phosphate dehydrogenase deficiency (G6PD) due to the risk of hemolytic anemia