Morphine Mouthwash for Management of Oral Mucositis in Patients With Head and Neck Cancer

Evaluating the Effectiveness of Topical Morphine Compared With a Routine Mouthwash in Managing Cancer Treatment-induced Mucositis in Patients With Head and Neck Cancer in Isfahan

Oral mucositis is a debilitating side effects of cancer treatment for which there is not much successful treatments at yet. The investigators are going to evaluate the effectiveness of topical morphine compared with a routine mouthwash in managing cancer treatment-induced mucositis. The investigators hypothesize that topical morphine is more effective and more satisfied by patients than the magic mouthwash in reducing severity of cancer treatment-induced oral mucositis.

Inclusion Criteria:

• Head and neck cancer patients
• Severe oral mucositis; grade III or IV of the World Health Organization (WHO) rating of global mucositis
• Willingness to participate

Exclusion Criteria:

• History of severe renal or hepatic insufficiency
• Collagen-vascular disease
• Allergic reaction to morphine
• Current smokers or alcohol users
• Pregnant women