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To assess the efficacy of polygonatum kingianum extract on endurance performance and anti-fatigue
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo drink | Placebo Comparator | consume 1 bottle per day |
|
| Polygonatum kingianum extract drink | Experimental | consume 1 bottle per day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo drink | Dietary Supplement | consume 1 bottle per day |
| |
| Measure | Description | Time Frame |
|---|---|---|
| The change of aerobic endurance | 3-min step test is used to assess aerobic endurance | Day 0, day 14, day28 |
| The change of continuous attention performance | Canon continuous attention software (Conners' Continuous Performance Test) is used to assess continuous attention performance | Day 0, day 14, day28 |
| The change of concentration of testosterone in blood | Fasting venous blood was sampled to measure concentrations of testosterone | Day 0, day 14, day28 |
| The change of blood PDE5 gene expression | Fasting venous blood was sampled to measure the expression of PDE5 gene | Day 0, day 14, day28 |
| Measure | Description | Time Frame |
|---|---|---|
| The change of blood nitric oxide (NO) | Fasting venous blood was sampled to measure concentrations of nitric oxide | Day 0, day 14, day28 |
| The change of self-assessment fatigue condition | A 10 point likert scale was utilized to evaluate fatigue condition. The higher the score, the higher the fatigue level. |
| Measure | Description | Time Frame |
|---|---|---|
| The change of concentrations of liver function biomarkers (AST, ALT) in blood | Fasting venous blood was sampled to measure the concentration of liver function biomarkers- Aspartate amino transferase (AST), Alanine amino transferase (ALT). | Day 0, day 14, day28 |
| The change of concentrations of renal function biomarkers (BUN, creatinine) in blood |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bo-han Wu | National Pingtung University of Science and Technology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Pingtung University of Science and Technology | Pingtung City | Taiwan |
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| ID | Term |
|---|---|
| D005221 | Fatigue |
| ID | Term |
|---|---|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Polygonatum kingianum extract drink |
| Dietary Supplement |
consume 1 bottle per day |
|
|
| Day 0, day 14, day28 |
Fasting venous blood was sampled to measure the concentration of renal function biomarkers- Blood Urea Nitrogen (BUN), creatinine. |
| Day 0, day 14, day28 |
| The change of concentrations of blood lipid profiles (total cholesterol, LDL-C, HDL-C, triglyceride) | Fasting venous blood was sampled to measure lipid profiles- total cholesterol, Low Density Lipoprotein-Cholesterol (LDL-C), High Density Lipoprotein-Cholesterol (HDL-C), triglyceride. | Day 0, day 14, day28 |