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This study investigates the effects of green tea extract and ginger supplementation, both individually and in combination, on endurance performance, metabolism, thermal comfort, and muscle soreness in recreationally active young men. Participants will complete cycling tests under both normal room temperature (21-24°C) and cold (5-7°C) conditions. The study uses a randomized, double-blind, placebo-controlled, crossover design to compare the outcomes of placebo, green tea, ginger, and combined supplementation. The findings may help to identify nutritional strategies that improve exercise performance and comfort in different environmental conditions.
This randomized, double-blind, placebo-controlled, crossover trial is designed to evaluate the effects of green tea extract and ginger supplementation, both individually and in combination, on endurance performance, metabolic responses, thermal sensation, and muscle soreness in recreationally active men.
Sixteen healthy participants will complete eight experimental conditions: placebo, green tea extract (500 mg), ginger (1 g), and a combination of both, tested under normal (21-24°C) and cold (5-7°C) environments. Each condition will be separated by a washout period to avoid carryover effects.
Endurance capacity will be measured using a time-to-exhaustion cycling test at 70% of maximal oxygen uptake (VOâ‚‚max). Metabolic responses will be assessed by gas analysis to determine respiratory exchange ratio (RER). Perceptual measures will include the Borg Rating of Perceived Exertion (RPE) and a thermal sensation scale, while muscle soreness will be evaluated 24 hours post-exercise using a visual analog scale (VAS).
The study aims to determine whether the combined intake of green tea and ginger provides synergistic benefits over individual supplementation, particularly in cold environments where thermoregulation and endurance capacity are challenged. Findings may contribute to practical nutritional strategies that enhance exercise performance, comfort, and recovery under environmental stress conditions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo Arm | Placebo Comparator | Participants receive a placebo consisting of maltodextrin in capsule form, matched in appearance and taste to the active supplements. |
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| Green Tea Extract Arm | Experimental | Participants receive 500 mg of standardized green tea extract in capsule form. |
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| Ginger Arm | Experimental | Participants receive 1 g of ginger supplement in capsule form. |
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| Combined Supplement Arm | Experimental | Participants receive a combination of 500 mg green tea extract and 1 g ginger, both administered in capsule form. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo Arm | Dietary Supplement | Participants receive a placebo consisting of maltodextrin in capsule form, matched in appearance and taste to the active supplements. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Time to Exhaustion (TTE) | Endurance performance assessed as the total time in seconds participants are able to maintain cycling at 70% of VOâ‚‚max on a cycle ergometer, until volitional exhaustion defined as the inability to sustain a cadence of 60 rpm for 10 consecutive seconds | Immediately during each exercise test session (after supplement ingestion, under normal and cold environmental conditions) |
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Inclusion Criteria:
Male participants aged 18-35 years
Recreationally active (≥3 aerobic exercise sessions per week, ≥30 minutes per session, for at least 6 months)
VOâ‚‚max between 40-50 mL/kg/min (recreationally active fitness level)
Body mass index within the normal to slightly overweight range (approximately 18.5-27.5 kg/m²)
Willingness to comply with study requirements, including supplementation and exercise testing protocols
Provided written informed consent
Exclusion Criteria:
History of cardiovascular, respiratory, metabolic, or neurological disorders
Allergy or intolerance to green tea, ginger, or maltodextrin
Current use of ergogenic supplements, medications affecting metabolism, or stimulants (e.g., beta-blockers, caffeine pills)
Smoking or excessive alcohol consumption (>14 units per week)
Inconsistent exercise habits (<3 sessions/week in the past 6 months)
Participation in another clinical trial within the past 3 months
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Erzurum Technical University Sport Sciences Faculty | Erzurum | Erzurum | 25240 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41010475 | Derived | Demirli A, Ulupinar S, Terzi M, Ozbay S, Ozkara AB, Gencoglu C, Ouergui I, Ardigo LP. Synergistic Effects of Green Tea Extract and Ginger Supplementation on Endurance Performance and Thermal Perception in Normothermic and Cold Environments: A Randomized, Placebo-Controlled, Double-Blind Crossover Trial. Nutrients. 2025 Sep 13;17(18):2949. doi: 10.3390/nu17182949. |
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| ID | Term |
|---|---|
| D013662 | Tea |
| C000713927 | ginger extract |
| ID | Term |
|---|---|
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
| D001628 | Beverages |
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| Green Tea Extract | Dietary Supplement | Participants receive 500 mg of standardized green tea extract in capsule form. |
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| Ginger | Dietary Supplement | Participants receive 1 g of ginger supplement in capsule form. |
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| Combined Supplement (Green Tea + Ginger) | Dietary Supplement | Participants receive a combination of 500 mg green tea extract and 1 g ginger, both administered in capsule form. |
|
| D000066888 |
| Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |