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This research is examining the changes in muscle size, muscle function, body composition, strength, and blood vessel health. Specifically, the changes in these variables over the course of 8 weeks of training with or without blood flow restriction (BFR) and the supplementation of creatine or placebo (dextrose, a sugar in the form of a powder which is the standard placebo). Creatine monohydrate (Cr) is the most popular supplement for athletes and benefits all populations, however women are still very hesitant to take it due to the misconception of weight gain. This study will look to measure those muscle and body changes with exercise.
We expect that you will be in this research study for an estimated 10 weeks, with 27 visits total. You will be asked to complete questionnaires, blood draws, and perform exercises using exercise machines for testing the strength of your legs while using a blood pressure cuff during some of these exercises. Other tests in this study will measure hydration (water in your system) status, your nervous system, and body composition percentage (bone/muscle tissue/fat tissue). Specifically, you will be asked to attend:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | No Intervention | If you are in the control group, there will be no supplement or exercise procedures. You will be asked to come in to the lab for 5 visits | |
| Creatine and Blood Flow Restriction Exercise | Experimental |
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| Creatine and No-BFR with Training | Active Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Creatine Monohydrate | Dietary Supplement | Creatine supplementation for 8 weeks, 5g daily. A 5 day loading phase will be implemented with 20g daily for 5 days. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Strength | isokinetic dynanometer | Pre, 5-Days post loading, 4wk, 8wk |
| Body Composition | BIS, BodPod | Pre, 5-Days post loading, 4wk, 8wk |
| Neuromuscular Function | EMG | Pre, 5-Days post loading, 4wk, 8wk |
| Endothelial Function | Flow Mediated Dilation | Pre, 5-Days post loading, 4wk, 8wk |
| Measure | Description | Time Frame |
|---|---|---|
| Mood States | Mood Assessed via administration of the POMS Questionnaire. 58 words or phrases are presented in a Likert format questionnaire reflecting how the subject feels at the time of completing the questionnaire. Scores range from 0 (Not at all) to 4 (Extremely). Tension, depression, anger, vigor, fatigue, confusion and total mood disturbance (TMD) will be measured. | Pre, 5-Days post loading, 4wk, 8wk |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Paola M Rivera | University of Central Florida | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Central Florida | Orlando | Florida | 32816 | United States |
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| ID | Term |
|---|---|
| D057185 | Sedentary Behavior |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D003401 | Creatine |
| D000090003 | Blood Flow Restriction Therapy |
| D015444 | Exercise |
| ID | Term |
|---|---|
| D006146 | Guanidines |
| D000578 | Amidines |
| D009930 | Organic Chemicals |
| D000596 | Amino Acids |
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double blind placebo controlled
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| Placebo and Blood Flow Restriction Exercise | Placebo Comparator |
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| Placebo and No-BFR with Training | Sham Comparator |
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| Blood Flow Restriction | Device | Blood Flow Restriction Cuffs applied during exercise |
|
| Exercise | Other | Participants will exercise |
|
| D000602 |
| Amino Acids, Peptides, and Proteins |
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
| D005791 | Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |