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Evaluate the improvement of regulation of skin and blood index composition after consumption of Omegia® Softgel
The blood biochemical analysis at Weeks 0 and 12, including Catalase, Tumor necrosis factor-α, Cholesterol, Triglyceride, High-density lipoprotein-Cholesterol and Low-density lipoprotein- Cholesterol.
The Skin assessment at Weeks 0, 4 and 12, including Skin brightness, Skin redness sensitivity index, Skin moisture, Skin elasticity, Facial skin pores, Facial skin texture and Skin collagen content.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Omegia® Softgel -A | Placebo Comparator | Take Omegia® Softgel -A once a day for 12 weeks |
|
| Omegia® Softgel -B | Experimental | Take Omegia® Softgel-B once a day for 12 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Omegia® Softgel -B | Dietary Supplement | How to use: Take once a day for 12 weeks Subject precautions: If the health products and cosmetic care products used contain sea buckthorn ingredients, stop using them. |
| Measure | Description | Time Frame |
|---|---|---|
| Skin brightness | Skin color difference analyzer (Chroma Meter MM500) was utilized to measure skin brightness. Units: arbitrary units | Subjects will be tested in the 4th week |
| Skin redness | Skin color difference analyzer (Chroma Meter MM500) was utilized to measure skin redness. Units: arbitrary units | Subjects will be tested in the 4th week |
| Skin moisture | Skin moisture meter (Corneometer CM825) was utilized to measure skin moisture. Units: arbitrary units | Subjects will be tested in the 4th week |
| Skin elasticity | Skin elastometer (Soft Plus) was utilized to measure skin elasticity. Units: arbitrary units | Subjects will be tested in the 4th week |
| Facial skin pores | VISIA Micro-Analysis Skin Image Analyzer was utilized to measure skin pores. Units: arbitrary units | Subjects will be tested in the 4th week |
| Facial skin texture | VISIA Micro-Analysis Skin Image Analyzer was utilized to measure skin texture. Units: arbitrary units | Subjects will be tested in the 4th week |
| Skin collagen content | Subcutaneous collagen scanner (DermaLab® Series SkinLab Combo) was utilized to measure skin collagen. Units: arbitrary units | Subjects will be tested in the 4th week |
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Inclusion Criteria:
● Female subjects older than 45 years
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chia Nan University of Pharmacy ＆ Science | Tainan | 71710 | Taiwan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17373178 | Background | Gold MH, Goldman MP, Biron J. Efficacy of novel skin cream containing mixture of human growth factors and cytokines for skin rejuvenation. J Drugs Dermatol. 2007 Feb;6(2):197-201. | |
| 26393899 | Background | Rodrigues F, Sarmento B, Amaral MH, Oliveira MB. Exploring the antioxidant potentiality of two food by-products into a topical cream: stability, in vitro and in vivo evaluation. Drug Dev Ind Pharm. 2016;42(6):880-9. doi: 10.3109/03639045.2015.1088865. Epub 2015 Sep 22. |
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| ID | Term |
|---|---|
| D012877 | Skin Manifestations |
| D001248 | Asthenopia |
| D014623 | Vaginal Diseases |
| ID | Term |
|---|---|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D005128 | Eye Diseases |
| D005831 | Genital Diseases, Female |
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| Omegia® Softgel -A | Dietary Supplement | How to use: Take once a day for 12 weeks Subject precautions: If the health products and cosmetic care products used contain sea buckthorn ingredients, stop using them. |
|
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |