The objective of this study are to evaluate efficacy and safety of protein product in volunteers with sarcopenia.

There are 45 patients in this study. They are randomly divided into 3 groups which are whey protein isolate group, isolated soy protein group, placebo group. They will take the sample 1 sachet/day for 12 weeks. Muscle strength, muscle mass, physical performance, sarcopenia score, body weight, body mass index, protein, immunoglobulins, quality of life, liver function, kidney function, other laboratory value, and adverse effects are evaluated.

Inclusion Criteria:

• Age more than 20 years
• Sarcopenia score more than 4
• Handgrip strength less than 28 kg in male and less than 18 kg in female and muscle mass less than 7 kg/m2 in male and less than 5.7 kg/m2 in female or Gait speed (6-meter walk) less than 1 m/s
• Can take protein from animal
• Can read and write or have people to look after
• Willing to participate in this study

Exclusion Criteria:

• Allergic to protein from animals and plants
• Hepatitis or cirrhosis
• Glomerular disease or glomerular filtration rate less than 60 ml/min/1.73m2
• Cancer or heart disease
• Cannot walk
• Pregnancy and lactation
• Duodenal surgery
• Take protein supplement within 2 weeks
• Take protein in normal food more than 1.2 g/body weight/day
• Participating in other studies