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This study aims to find out the role of plasma I-FABP level, SOFA score, fluid balance, and vasopressor dose in predicting gastrointestinal dysfunction in high-risk postoperative patients treated in ICU
This is a prospective cohort study to find out the role of plasma I-FABP level, SOFA score, fluid balance, and vasopressor dose in predicting gastrointestinal dysfunction in high-risk postoperative patients treated in ICU. The characteristics of patients who meet the eligibility criteria were obtained. Blood sampling during admission is done for I-FABP level measurement and will be repeated after 24 hours. Blood sample which is not directly processed will be stored in refrigerator under 6-8C temperature. Evaluation of Acute Gastrointestinal Injury signs and symptoms is done. The re-evaluation is performed every day. If patients experiencing AGI signs and symptoms, monitoring and treatment based on condition are done. Routine follow-up is continued during hospitalisation in ICU. After all sample are collected, I-FABP level is assessed quantitatively using ELISA.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experience gastrointestinal dysfunction | Gastrointestinal dysfunction is defined as acute gastrointestinal injury (AGI) score >= 2 based on ESICM criteria, monitored within 72 hours according to early postoperative gastrointestinal dysfunction. Experience gastrointestinal dysfunction = AGI score >=2 | ||
| Did not experience gastrointestinal dysfunction | Did not experience gastrointestinal dysfunction = AGI score <2 |
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| Measure | Description | Time Frame |
|---|---|---|
| I-FABP plasma level | I-FABP plasma level is measured during admission and 24 hours after. I-FABP plasma level during admission is used as the data, while the 24 hours after admission is used to evaluate any bowel injury during treatment in ICU. | During admission |
| I-FABP plasma level | I-FABP plasma level is measured during admission and 24 hours after. I-FABP plasma level during admission is used as the data, while the 24 hours after admission is used to evaluate any bowel injury during treatment in ICU. | 24 hours after admission |
| Vasopressor dose | Mean dose of norepinephrine (mcg/kg/min) used during intraoperative period. It is measured proportionally to the duration of use based on anesthesia record. | During surgery (intraoperative period) |
| SOFA score | Score used to evaluate patients' status during treatment in ICU and to determine the severity of organ dysfunction. It is measured during patients' admission to ICU | During admission in ICU (postoperative period) |
| Fluid balance | The net between fluid output and input during intraoperative period. | During surgery (intraoperative period) |
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Inclusion Criteria:
Exclusion Criteria:
Drop-out Criteria
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High-risk postoperative patients treated in Intensive Care Unit of Emergency Department or Surgery Unit in Cipto Mangunkusumo General Hospital who meet eligibility criteria
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Aldy Heriwardito, MD | Contact | 3143336 | 6221 | aldy.heriwardito@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Aldy Heriwardito, MD | Fakultas Kedokteran Universitas Indonesia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cipto Mangunkusumo Central National Hospital | Recruiting | Jakarta Pusat | Jakarta Special Capital Region | 10430 | Indonesia |
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| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Intestinal fatty-acid binding protein (I-FAPB) is expressed in epithelial cells of the mucosal layer of the small intestine tissue.