Breathing Training and Exercise Capacity in Non-CFB

Home-based, Digitally Delivered Breathing Training in People With Non-cystic Fibrosis Bronchiectasis: A Randomized Control Trial

The purpose of this research is to investigate whether a home-based and health coach supported specific breathing and respiratory muscle training program improves the ability to exercise, the function of the lungs and breathing muscles, and general clinical status in people with non-cystic fibrosis bronchiectasis (non-CFB).

Inclusion Criteria:

• Mayo Clinic patient with confirmed diagnosis of Non-Cystic Fibrosis Bronchiectasis (non-CFB): Non-CFB as confirmed by clinical history, including cough, shortness of breath, exertional dyspnea, pulmonary function tests, and high-resolution computed tomography. Patients will be considered clinically stable if there is no evidence of an exacerbation or change(s) in medical therapy in the previous three weeks.
• Able and willing to provide informed consent to participate in the study.

Exclusion Criteria:

• Presence of significant coexisting disease, neurological conditions, and/or orthopedic complications that affect ability to undertake exercise.
• Presence of advanced heart failure.
• Current use of antibiotics.
• Acute exacerbation(s) within 3-weeks prior to study commencement.
• Participation within a pulmonary rehabilitation program within 6-months prior to study commencement.