Vitamin D Supplementation in Episodic and Chronic Tension-type Headache

Evaluation of Vitamin D Supplementation in Patients With Episodic and Chronic Tension-type Headache.

The goal of this clinical trial is to learn about the effect of vitamin D in patients with prophylactic therapy for episodic and chronic tension-type headache in amitriptyline or topiramate treatment. The main question it aims to answer are:

• What is the effect of vitamin D in patients with prophylactic therapy for episodic and chronic tension-type headache?

Patients will have the next selection criteria:

• Patients diagnosed by a neurologist in the headache clinic
• Criteria for episodic and chronic tension-type headache
• Poor clinical response to prophylactic treatment (amitriptyline, topiramate)
• Use of at least 1 prophylactic medication or a history of having used them.
• Onset of disease between the ages of 18 and 60
• Signature of informed consent

The population will be randomly divided into the following 3 treatment groups:

• Participants amitriptyline or topiramate treatment.
• Patients with placebo (Calcium) + topiramate/amitriptyline,
• Participants with vitamin D3/calcium+topiramate/amitriptyline. Researchers will compare the groups to see if vitamin D can decrease the intensity of your headache and therefore have a new therapeutic option.

It will be a 4 month study. Each month a package containing treatment will be delivered, which may be conventional medication or tablets with conventional medication added with vitamins.

Inclusion Criteria:

• Patients diagnosed by a neurologist in the headache clinic
• Criteria for episodic and chronic tension-type headache
• Poor clinical response to prophylactic treatment (amitriptyline, topiramate)
• Use of at least 1 prophylactic medication or a history of having used them.
• Onset of disease between the ages of 18 and 60
• Signature of informed consent

Exclusion Criteria:

• Patients with secondary headache (cranioencephalic trauma, cerebral infarction)
• Patients with primary headache other than tension headache
• Suffer heart, liver, and kidney diseases.
• Medications: thiazides
• Pregnant women
• They do not want to participate