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The primary purpose of the study is to explore whether a lower home blood pressure target (125/75 v.s. 135/85 mmHg) would be beneficial to elderly treated hypertensive patients in terms of reduced incidence of cardiovascular events. The study also aims to promote the application of standardised and information-based home blood pressure monitoring in community hypertension management.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intensive Home BP Control | Experimental | Participants randomized into the intensive treatment arm will have a goal of home BP<125/75 mmHg. |
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| Standard Home BP Control | Active Comparator | Participants randomized into the standard treatment arm will have a goal of home BP within 125-134/75-84 mmHg. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intensive Home BP control | Drug | If the target home BP level is not achieved during the follow-up periods, type and dosage of antihypertensive drugs will be adjusted according to current guidelines and physician's clinical experience. |
| Measure | Description | Time Frame |
|---|---|---|
| Composite of adverse cardiovascular events | Composite of major adverse cardiovascular events consisting of death from cardiovascular diseases, non-fatal stroke, myocardial infarction, coronary revascularization (percutaneous coronary intervention [PCI], coronary artery bypass grafting [CABG]), hospitalization for heart failure or unstable agina. | 48 months |
| Measure | Description | Time Frame |
|---|---|---|
| Components of the primary outcome | Occurrence of any components of the primary outcome (death from cardiovascular diseases, non-fatal stroke, myocardial infarction, coronary revascularization (percutaneous coronary intervention [PCI], coronary artery bypass grafting [CABG]), hospitalization for heart failure or unstable agina). | 48 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yan Li, Professor | Contact | +8613482234463 | liyanshcn@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Yan Li, Professor | Shanghai Institute of Hypertension | Principal Investigator |
| Jiguang Wang, Professor | Shanghai Institute of Hypertension | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Community hospitals | Recruiting | Shanghai | Shanghai Municipality | 200025 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39993302 | Derived | Zhang DY, Zhang YQ, An DW, Cheng YB, Tang ST, Liu M, Li J, Staessen JA, Wang JG, Li Y; HomeBP Trial Investigators. A randomised trial comparing usual versus strict home blood pressure control in elderly patients with hypertension: protocol and initial progress. Blood Press. 2025 Dec;34(1):2472192. doi: 10.1080/08037051.2025.2472192. Epub 2025 Mar 2. |
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| Standard Home BP control | Drug | If the target home BP level is not achieved during the follow-up periods, type and dosage of antihypertensive drugs will be adjusted according to current guidelines and physician's clinical experience. |
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| Renal outcome | Including end stage renal disease (ESRD) and a decrease in the eGFR of 30% or more | 48 months |
| Adverse or severe adverse events | Especially dizziness and falls caused by hypotension, and orthostatic hypotension | 48 months |