Feasibility of Implementing Time-restricted Eating in Women With Mild Cognitive Impairment

Feasibility of Implementing Time-restricted Eating in Women With Mild Cognitive Impairment

This study will investigate the feasibility of implementing a time-restricted eating intervention in females with mild cognitive impairment. Targeted therapeutic interventions that improve cognitive impairment and delay onset of ADRD are particularly important for females, who have twice the lifetime risk of developing AD, compared to males.

This study will investigate the feasibility of implementing a time-restricted eating (TRE) intervention in females with mild cognitive impairment. Data will be collected for 10 weeks. Baseline food timing, activity/sleep, metabolic health (fasting labs and anthropometric measures), and cognitive testing will be collected in the first two weeks. Subjects will then be invited to enroll in a TRE intervention for 8 weeks. Subjects will be educated about the potential health benefits of TRE, and then each subject will self-select a 10-hr window and consume all daily calories during this time frame. Subjects will text the time of their first and last daily calories for the duration of the study. At the end of the 8-week TRE intervention, metabolic, anthropometric, activity/sleep, and cognitive measurements will be collected.

Inclusion Criteria:

• Postmenopausal Women
• Age 45-95
• Diagnosis of mild cognitive impairment

Exclusion Criteria:

• Individuals prone to hypoglycemia
• Liver disease
• Taking medications that affect eating behaviors
• Alcohol consumption of >2 drinks per day
• Significant circadian disruption
• Having care-taking responsibilities that significantly affect sleep
• Shift work or irregular lifestyle
• Diagnosed clinical eating disorder
• Participating in a formal weight loss program