Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Tranexamic acid in debridement surgery of burns on the volume of bleeding in transfusion requirements
A randomized, double-blind, prospective trial was conducted to establish the effect of intraoperative tranexamic acid in the early surgical debridement of severe burns. The study was carried out between the months of January 2022 and December 2023.
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| tranexamic acid | Experimental | A total of 20 patients were included: 9 patients in the tranexamic acid group |
|
| placebo | Placebo Comparator | A total of 20 patients were included: 11 patients in the control group using 0.9% isotonic saline solution. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tranexamic acid | Drug | 10mg/kg intravenous single dose |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Compare the group with tranexamic acid with the group with saline solution. | The differences between the groups at the beginning of the study were evaluated with the Student's t test for continuous variables, and the proportions were compared with the Chi2 or Fisher test. | The time frame: the total time of the study is during the first day, only one dose will be given, and they will be compared at 24 hours. |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Alejandro Gonzalez-Ojeda, PhD | Contact | 33 312 941 65 | 52 | avygail5@gmail.com |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centro Médico Nacional de Occidente | Recruiting | Guadalajara | Jalisco | 44329 | Mexico |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27827518 | Background | Dominguez A, Alsina E, Landin L, Garcia-Miguel JF, Casado C, Gilsanz F. Transfusion requirements in burn patients undergoing primary wound excision: effect of tranexamic acid. Minerva Anestesiol. 2017 Apr;83(4):353-360. doi: 10.23736/S0375-9393.16.10992-7. Epub 2016 Nov 9. | |
| 34952736 | Background | K S A, Kumar P, Subair M, Sharma RK. Effect of single dose intravenous tranexamic acid on blood loss in tangential excision of burn wounds - A double blind randomised controlled trial. Burns. 2022 Sep;48(6):1311-1318. doi: 10.1016/j.burns.2021.08.021. Epub 2021 Aug 30. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D002056 | Burns |
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
Not provided
Not provided
| ID | Term |
|---|---|
| D014148 | Tranexamic Acid |
| ID | Term |
|---|---|
| D003509 | Cyclohexanecarboxylic Acids |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
Not provided
Not provided
Randomized, double-blind, prospective trial to establish the effect of intraoperative tranexamic acid in early surgical debridement of severe burns. The study was carried out between the months of January 2022 to December 2022.
Not provided
Not provided
Not provided
| 0.9% isotonic saline solution |
| Other |
100 ml intravenous single dose |
|
| 34740174 | Background | Brown NJ, Choi EH, Gendreau JL, Ong V, Himstead A, Lien BV, Shahrestani S, Ransom SC, Tran K, Tafreshi AR, Sahyouni R, Chan A, Oh MY. Association of tranexamic acid with decreased blood loss in patients undergoing laminectomy and fusion with posterior instrumentation: a systematic review and meta-analysis. J Neurosurg Spine. 2021 Nov 5;36(4):686-693. doi: 10.3171/2021.7.SPINE202217. Print 2022 Apr 1. |
| 35339324 | Result | Tapking C, Hundeshagen G, Kirchner M, Fischer S, Kneser U, Bliesener B. Tranexamic acid reduced blood transfusions in acute burn surgery: A retrospective case-controlled trial. Burns. 2022 May;48(3):522-528. doi: 10.1016/j.burns.2022.03.002. Epub 2022 Mar 16. |
| 39721243 | Derived | Castillo-Cardiel G, Avalos-Lopez M, Mendez-Miranda C, Gil-Vigna JA, Fuentes-Orozco C, Cervantes-Guevara G, Cervantes-Perez E, Ramirez-Ochoa S, Alvarez-Villasenor AS, Cortes-Flores AO, Morfin-Meza KD, Garcia A, Vazquez-Sanchez SJ, Gonzalez-Ojeda A. Comparative efficacy of tranexamic acid versus placebo on hemostatic outcomes after the surgical debridement of burn patients: A randomized controlled clinical trial. Burns. 2025 Mar;51(2):107339. doi: 10.1016/j.burns.2024.107339. Epub 2024 Nov 30. |