Tranexamic Acid in Major Vascular Surgery

Tranexamic Acid in Major Vascular Surgery. A Randomized Placebo-controlled Trial.

The purpose of this study is to determine whether tranexamic acid is effective in reducing intraoperative blood loss and necessity for haemotransfusion in patients undergoing open abdominal aortic aneurysm repair

Inclusion Criteria:

• Age > 50
• Able to give written informed consent
• Undergoing open abdominal aortic aneurysm repair

Exclusion Criteria:

• Patients participating in a pharmaceutical clinical trial in the last 3 months
• Urgent/emergent surgery
• Allergy/intolerance to tranexamic acid
• History of seizures
• Acute Venous or Arterial Thrombosis
• Fibrinolytic conditions due to consumption coagulopathy
• Disseminated intravascular coagulation
• Haematuria
• Visual disturbances