Large Cohort of 1000 Patients With Severe Myopia

Large Cohort of 1000 Patients With Severe Myopia

The prevalence of myopia and severe myopia are increasing and will affect 50% and 10% of the population respectively. Severe myopia exposes an increased risk of glaucoma, cataract, retinal detachment and myopic maculopathy, a source of visual impairment.

To date, no European cohort study has been conducted to estimate the rate of these complications and to study the predictive parameters.

This study allows to describe the evolution of different ophthalmological parameters of a population of strong myopes during their follow-up for 10 years using multimodal imaging techniques of the retina.

Prospective, longitudinal, multicentric, non-randomized cohort study with constitution of a biological collection.

This study will include major and minor patients with high myopia

Inclusion Criteria:

• Age ≥ 6 years

• Severe myopia in at least one eye, defined as

  • a refractive error ≤ -6.00 diopters OR
  • an axial length ≥ 26.50 mm

• Follow-up performed at at least one of the participating centers

• Express consent to participate in the study

• If age < 18 years: express consent of the person(s) exercising parental authority

• Affiliated or beneficiary of a health insurance

Exclusion Criteria:

• Visual acuity < 5 letters on the ETDRS (equivalent to "finger count" or less) in both eyes
• Disorders of the transparent media in both eyes with opacities that may affect image quality
• Syndromic myopia of genetic origin (Stickler syndrome type 1 and 2, Marfan syndrome, Ehler-Danlos disease type 4, Knobloch syndrome) or inherited retinal dystrophy (X-linked retinitis pigmentosa, congenital stationary night blindness of Schubert-Bornshein type, Bornholm eye disease)
• Patient who does not wish to continue to be followed in one of the participating centers
• Patient benefiting from a legal protection measure
• Pregnant or breastfeeding woman