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Neurocognitive disorders and hypertension occur commonly with aging. While, by definition, older adults are at high cardiovascular risk, there is no guideline exist currently on blood pressure management of elderly hypertension. However, studies have shown that in aging adults, high blood pressure helps prevent against cognitive decline, and low blood pressure on antihypertensive drugs could accelerate it. This study aims at investigating if pharmacological treatment of hypertension in the very elderly is influenced by presence and severity of neurocognitive disorders. Our research hypothesis is that the drug management of hypertension in patients 80 years of age or older more is all the less aggressive as the neurocognitive disorders are advanced.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control group | absence of neurocognitive disorder (ND), Mini-Mental State Examination (MMSE) from 27 to 30 inclusive |
| |
| mild neurocognitive disorder | MMSE from 21 to 26 inclusive |
| |
| moderate neurocognitive disorder | MMSE from 11 to 20 inclusive |
| |
| severe neurocognitive disorder | MMSE less than or equal to 10 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Antihypertensive Agents | Drug | number of hypertensive drugs |
|
| Measure | Description | Time Frame |
|---|---|---|
| number of antihypertensive agents | among ACEI/ARB2, calcium channel blocker, thiazides and related, central antihypertensive beta blocker | during inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| class of antihypertensive medications | among ACEI/ARB2, calcium channel blocker, thiazides and related, central antihypertensive beta blocker | during inclusion |
| systolic and diastolic blood pressure |
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Inclusion Criteria:
Exclusion Criteria:
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All patients aged 80 years or more and hypertensive who received a Comprehensive Geriatric Assessment (including a mini mental state examination) as part of a frailty, memory or oncogeriatric assessment, in day hospital in the geriatric department in University Hospital of Nancy in 2022.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Régional Universitaire de Nancy | Nancy | 54000 | France |
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| ID | Term |
|---|---|
| D019965 | Neurocognitive Disorders |
| D003704 | Dementia |
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D001523 | Mental Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D000959 | Antihypertensive Agents |
| ID | Term |
|---|---|
| D002317 | Cardiovascular Agents |
| D045506 | Therapeutic Uses |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
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blood pressure measured with upper arm cuffs
| during inclusion |
| orthostatic hypotension | a systolic blood pressure decrease of at least 20 mm Hg or a diastolic blood pressure decrease of at least 10 mm Hg within three minutes of standing | during inclusion |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |