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Older adults are at increased risk of high blood pressure and cognitive decline. High blood pressure itself also increases risk of cognitive decline. A particular type of blood pressure lowering drug (a calcium channel blocker(CCB)) may lower risk of dementia in younger adults but there is no clear evidence of it's impact in those >=80. It is important that we know whether CCB use impacts on cognitive function in this age group. This study will examine the impact of antihypertensives on change in cognitive function with a particular focus on CCBs.
This study is an observational cohort study examining cognitive change in those participants taking antihypertensives and aged 80 and over and examining cognitive change in participants taking different types of antihypertensive medication.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cohort of older adults taking antihypertensives | Adults aged 80 and over treated with antihypertensive drugs |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in Cognitive Function as Measured Using the Extended Mini Mental State Exam | The change in cognitive function measured using the extended mini-mental state exam (this is an extended screening test which assesses several areas of cognitive function, the scale is from 0-100, higher scores are better, those without cognitive impairment would be expected to score close to maximum) | 12 months |
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Inclusion Criteria:
Aged 80 and over Receiving pharmacological treatment for hypertension Mini Mental State Exam score >24 No other condition likely to limit life to less than one year or to prevent the taking of informed consent.
Exclusion Criteria:
Aged under 80 years Not receiving pharmacological treatment for hypertension Mini Mental State Exam score <25 Diagnosed with a condition likely to limit life to less than one year or to prevent the taking of informed consent.
Presence of a sensory impairment or an existing neuropsychological deficit of sufficient severity to prevent cognitive testing.
Presence of a condition that will prevent cognitive testing, registered blind, profoundly deaf, suffering from an aphasia.
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UK Primary care
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| Name | Affiliation | Role |
|---|---|---|
| Ruth Peters, PhD | Imperial College London, UK | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Kiltearn Medical Centre | Nantwich | Cheshire | CW5 5NX | United Kingdom | ||
| Ashfields Primary Care Centre |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30728929 | Result | Peters R. No clear relationship between antihypertensive class and cognitive function over 12 months in a cohort study of community-dwelling adults aged 80 and over. Ther Adv Chronic Dis. 2019 Jan 31;10:2040622318820849. doi: 10.1177/2040622318820849. eCollection 2019. |
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Participants had hypertension and treatment with antihypertensives.The study examined the cognitive change in older adults taking antihypertensives with a particular focus on Calcium Channel Blockers (CCB). Cognitive function was tested at 0 & 12 months. Participation in the study had no impact on treatment.
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| ID | Title | Description |
|---|---|---|
| FG000 | Older Adult Cohort | Older adults receiving treatment with antihypertensive medication |
| Title | Milestones | Reasons Not Completed | |||||
|---|---|---|---|---|---|---|---|
| Overall Study |
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| Sandbach |
| Cheshire |
| CW11 BEQ |
| United Kingdom |
| Whitby Group Practice | Whitby | North Yorkshire | YO21 1SD | United Kingdom |
| South Axholme Practice | Epworth | Yorkshire | DN9 1EP | United Kingdom |
| Dr Moss and Partners | Harrogate | HG1 5JP | United Kingdom |
| Gale Farm Surgery | York | YO24 3BU | United Kingdom |
| Haxby Group Practice | York | YO32 2LL | United Kingdom |
| COMPLETED |
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| NOT COMPLETED |
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| ID | Title | Description |
|---|---|---|
| BG000 | Older Adult Cohort | Older adults receiving treatment with antihypertensive medication |
| Units | Counts |
|---|---|
| Participants |
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| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean | Standard Deviation | years |
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| Sex: Female, Male | Count of Participants | Participants |
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| Race/Ethnicity, Customized | Count of Participants | Participants |
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| Region of Enrollment | Count of Participants | Participants |
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| Extended Mini-Mental State Exam | The extended mini mental state exam is a widely used and validated cognitive screening tool. It is scored from 0-100 Higher values are better. A population without cognitive impairment would be expected to score near the maximum value. | Median | Inter-Quartile Range | units on a scale |
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| Systolic blood pressure | Mean | Standard Deviation | mmHg |
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| Diastolic blood pressure | Mean | Standard Deviation | mmHg |
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| Prescribed calcium channel blockers | Count of Participants | Participants |
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| Cardiovascular disease | Count of Participants | Participants |
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| Body Mass Index | Mean | Standard Deviation | kg/m^2 |
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| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Primary | Change in Cognitive Function as Measured Using the Extended Mini Mental State Exam | The change in cognitive function measured using the extended mini-mental state exam (this is an extended screening test which assesses several areas of cognitive function, the scale is from 0-100, higher scores are better, those without cognitive impairment would be expected to score close to maximum) | Regression analysis examining change in cognitive function in older adults taking antihypertensives, results are reported for those taking calcium channel blocker antihypertensives over one year of follow up. | Posted | Mean | 95% Confidence Interval | Change on a scale | 12 months |
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12 month
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Older Adult Cohort | Older adults receiving antihypertensive medication | 0 | 292 | 0 | 292 | 0 | 292 |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr Ruth Peters | Imperial College London | 07950289662 | r.peters@imperial.ac.uk |
| ID | Term |
|---|---|
| D006973 | Hypertension |
| D060825 | Cognitive Dysfunction |
| D003704 | Dementia |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| Black |
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| Unspecified |
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