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The aim of our study was to compare the effects of Lomber Epidural Analgesia (LEA), Transversus Abdominis Plane (TAP) block and Local Anesthetic Infiltration (LAI) on postoperative morphine consumption, time to first recue analgesic request, pain and patient satisfaction scores and side effects were compared in the patients undergoing major gynecologic/oncology lower abdominal surgery.
Following faculty ethical committee approval and written informed consent, 81 patients were included in our prospective, randomized and double-blind study. Patients were divided into 3 groups: lumbar epidural block (Group E), TAP block (Group T), and wound infiltration (Group I). Demographic data, surgical characteristics, hemodynamic values, pain scores at rest and on movement, morphine consumption, additional analgesic requirement, side effects at 1, 2, 6, 12, 24, 36 and 48th hours after surgery, and patient satisfaction scores at 24 and 48th hours were recorded.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| lumbar epidural analgesia with bupivacaine | Active Comparator | For postoperative analgesia; Lumbar epidural catheter inserted at L3-4 or L4-5 epidural space before anesthesia induction in the sitting position. After the end of surgery but approximately 20 minutes before extubation, 0.125% bupivacaine 20 ml administered through epidural catheter and the catheter was removed. |
|
| transversus abdominis plane block with bupivacaine | Active Comparator | For postoperative analgesia; After the end of surgery but before extubation, USD-guided TAP block was performed with 0.125% bupivacaine 20 ml to the anatomic neurofacial space between the internal oblique and transersus abdominis muscles, bilaterally (10 ml for each side). |
|
| wound infiltration with bupivacaine | Active Comparator | For postoperative analgesia; After the end of surgery but before extubation, 0.125% bupivacaine 20 ml administered to the surgical incision site. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| lumbar epidural analgesia with bupivacaine | Procedure | postoperative analgesic method |
|
| Measure | Description | Time Frame |
|---|---|---|
| morphine consumption | At the end of the surgery, the patients were allowed to use the patient controlled analgesia device (PCA). The PCA (CADD Legacy PCA pump, Smiths Medical MD, Inc. St. Paul, MN) was prepared with 40 mg morphine HCl in 100 ml saline. The PCA doses of morphine consisted of a bolus dose of 0.02 mg/kg every 15 minutes without a background infusion. Morphine consumption (mg) was evaluated and recorded postoperative 48 hours. | change from baseline morphine comsumption at 48 hours |
| Measure | Description | Time Frame |
|---|---|---|
| pain scores | postoperative pain scores of the patients were recorded using visual analog scale (VAS; 0=no pain, 10=worst pain) | change from baseline pain scores at 48 hours |
| patient satisfaction score |
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Inclusion Criteria:
Exclusion Criteria:
This study was conducted on female patients undergoing major abdominal gynecological surgery.
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| Name | Affiliation | Role |
|---|---|---|
| Hakkı - Unlugenc, Proffessor | Cukurova University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cukurova University | Adana | 01130 | Turkey (Türkiye) | |||
| Cukurova University |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D002045 | Bupivacaine |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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| transversus abdominis plane block with bupivacaine | Procedure | postoperative analgesic method |
|
| wound infiltration with bupivacaine | Procedure | postoperative analgesic method |
|
patient satisfaction scores were recorded using patient satisfaction scale (0= worst, 10=excellent)
| postoperative 24 and 48 hours |
| time to first rescue analgesic | If the patients complained of pain despite the analgesia regimen, iv 50 mg meperidine was given as a rescue analgesic. | postoperative 48 hours |
| side effects | all patients were visited after surgery in the ward and side effects were evaluated and recorded | postoperative 48 hours |
| Adana |
| Turkey (Türkiye) |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D000588 |
| Amines |