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Aging is associated with impairments in heat loss responses of skin blood flow and sweating leading to reductions in whole-body heat loss. Consequently, older adults store more body heat and experience greater elevations in core temperature during heat exposure at rest and during exercise. This maladaptive response occurs in adults as young as 40 years of age. Recently, heat acclimation associated with repeated bouts of exercise in the heat performed over 7 successive days has been shown to enhance whole-body heat loss in older adults, leading to a reduction in body heat storage. However, performing exercise in the heat may not be well tolerated or feasible for many older adults. Passive heat acclimation, such as the use of warm-water immersion may be an effective, alternative method to enhance heat-loss capacity in older adults. Thus, the following study aims to assess the effectiveness of a 7-day warm-water immersion (~40°C) protocol in enhancing whole-body heat loss in older adults. Warm-water immersion will consist of a one-hour immersion in warm water with core temperature clamped at 38.5°C. Improvements in whole-body heat loss will be assessed during an incremental exercise protocol performed in dry heat (i.e., 40°C, ~15% relative humidity) prior to and following the 7-day passive heat acclimation protocol. The incremental exercise protocol will consist of three 30 minute exercise bouts performed at increasing fixed rates of metabolic heat production (i.e., 150, 200, and 250 W/m2), each separated by 15-minutes of recovery, with exception final recovery will be 1-hour in duration) performed in a direct calorimeter (a device that provides a precise measurement of the heat dissipated by the human body).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Heat Acclimation | Experimental | Participants will undergo an exercise heat stress test prior to and following seven consecutive days of warm-water immersion (~40°C) of 1-hour duration with core temperature clamped at 38.5°C. During the exercise-heat stress test participants will perform three, successive 30-minute bouts of semi-recumbent cycling performed at increasing fixed loads of metabolic heat production of 150, 200 and 250 W/m2 (i.e., exercise bout 1, exercise bout 2 and exercise bout 3, respectively), each separated by 15-minute of rest break with the final recovery extended to 1-hour. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Heat acclimation | Other | Participants will complete a 7-day passive heat acclimation protocol consisting of immersion in warm water (~40°C) for 1 hour over 7 consecutive days. |
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| Measure | Description | Time Frame |
|---|---|---|
| Evaporative heat loss | Evaporative heat loss as assessed using a direct air calorimeter. | End of 30 minute exercise bout 1 (average of last 5 minutes). |
| Evaporative heat loss | Evaporative heat loss as assessed using a direct air calorimeter. | End of 30 minute exercise bout 2 (average of last 5 minutes). |
| Evaporative heat loss | Evaporative heat loss as assessed using a direct air calorimeter. | End of 30 minute bout 3 (average of last 5 minutes). |
| Whole-body heat loss | The sum of evaporative and dry heat exchange will be quantified during each exercise period (i.e., 150, 200 and 250 W/m2). | End of 30 minute exercise bout 1 (average of last 5 minutes). |
| Whole-body heat loss | The sum of evaporative and dry heat exchange will be quantified during each exercise period (i.e., 150, 200 and 250 W/m2). | End of 30 minute exercise bout 2 (average of last 5 minutes). |
| Whole-body heat loss | The sum of evaporative and dry heat exchange will be quantified during each exercise period (i.e., 150, 200 and 250 W/m2). | End of 30 minute exercise bout 3 (average of last 5 minutes). |
| Measure | Description | Time Frame |
|---|---|---|
| Body heat storage | Cumulative amount of heat stored within the body calculated as the temporal summation of metabolic heat production and net heat loss. | Change from start to end of 30 minute exercise bout 1 |
| Body heat content |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Glen P Kenny, PhD. | University of Ottawa | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Univerisity of Ottawa | Ottawa | Ontario | K1N6N5 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41549363 | Derived | Janetos K, O'Connor F, Morris N, Kenny G. The influence of heat acclimation on the relation and agreement between perceptual and physiological strain in older males during exercise-heat stress. Appl Physiol Nutr Metab. 2026 Jan 1;51:1-11. doi: 10.1139/apnm-2025-0360. | |
| 39820413 | Derived | Janetos KT, O'Connor FK, Meade RD, Richards BJ, Koetje NJ, Kirby NV, McCormick JJ, Flouris AD, Kenny GP. Short-Term Warm Water Immersion for Improving Whole-Body Heat Loss in Older Men. Med Sci Sports Exerc. 2025 Jun 1;57(6):1137-1147. doi: 10.1249/MSS.0000000000003649. Epub 2025 Jan 17. |
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Deidentified participant data will be made available with approved analysis plan and signed access agreement
Following publication of the main study report(s)
Approved analysis plan and signed access agreement
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| ID | Term |
|---|---|
| D000084462 | Hyperthermia |
| D018882 | Heat Stress Disorders |
| ID | Term |
|---|---|
| D001832 | Body Temperature Changes |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D014947 | Wounds and Injuries |
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Each participant will complete seven consecutive experimental sessions consisting of a passive heat acclimation involving a one hour immersion in warm water (~40°C) with core temperature clamped at 38.5°C. Prior to and following the passive heat acclimation protocol, study participants will perform an exercise-heat stress test (Days 0 and 8) to assess whole-body heat loss in a hot-dry environment (40°C, 15% relative humidity). The exercise protocol will consist of three successive 30-minute bouts of exercise performed at increasing rates of metabolic heat production (i.e., 150, 200 and 250 W/m2), each separated by a 15-minute rest break, with the final recovery 1-hour in duration.
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Data will be blinded prior to analysis.
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Cumulative amount of heat stored within the body calculated as the temporal summation of metabolic heat production and net heat loss.
| Change from start to end of 30 minute exercise bout 2 |
| Body heat storage | Cumulative amount of heat stored within the body calculated as the temporal summation of metabolic heat production and net heat loss. | Change from start to end of 30 minute exercise bout 3 |
| Cumulative body heat storage | Cumulative amount of heat stored within the body calculated as the temporal summation of metabolic heat production and net heat loss. | Change from baseline resting to end of exercise bout 3 |
| Dry heat loss | Dry heat loss as assessed using a direct air calorimeter. | End of 30 minute exercise bout 1 (average of last 5 minutes). |
| Dry heat loss | Dry heat loss as assessed using a direct air calorimeter. | End of 30 minute exercise bout 2 (average of last 5 minutes). |
| Dry heat loss | Dry heat loss as assessed using a direct air calorimeter. | End of 30 minute exercise bout 3 (average of last 5 minutes). |
| Core temperature | Core temperature indexed by rectal/visceral temperature | End of 30 minute exercise bout 1 (average of last 5 minutes). |
| Core temperature | Core temperature indexed by rectal/visceral temperature | End of 30 minute exercise bout 2 (average of last 5 minutes). |
| Core temperature | Core temperature indexed by rectal/visceral temperature | End of 30 minute exercise bout 3 (average of last 5 minutes). |
| Change in core temperature | Core temperature indexed by rectal/visceral temperature | Change from baseline resting to end of end of 30 minute exercise bout 3. |
| Skin temperature | Skin temperature measured at 4-sites (chest, upper arm, thigh, calf) with mean value calculated as weighted value of 4 sites - upper arm, 30%; chest, 30%; thigh, 20%; and calf, 20%. | End of 30 minute exercise bout 1 (average of last 5 minutes). |
| Skin temperature | Skin temperature measured at 4-sites (chest, upper arm, thigh, calf) with mean value calculated as weighted value of 4 sites - upper arm, 30%; chest, 30%; thigh, 20%; and calf, 20%. | End of 30 minute exercise bout 2 (average of last 5 minutes). |
| Skin temperature | Skin temperature measured at 4-sites (chest, upper arm, thigh, calf) with mean value calculated as weighted value of 4 sites - upper arm, 30%; chest, 30%; thigh, 20%; and calf, 20%. | End of 30 minute exercise bout 3 (average of last 5 minutes). |
| Change in skin temperature | Skin temperature measured at 4-sites (chest, upper arm, thigh, calf) with mean value calculated as weighted value of 4 sites - upper arm, 30%; chest, 30%; thigh, 20%; and calf, 20%. | Change from baseline resting to end of end of 30 minute exercise bout 3. |
| Heart rate | Measured continuously with chest-band device | End of 30 minute exercise bout 1 (average of last 5 minutes). |
| Heart rate | Measured continuously with chest-band device | End of 30 minute exercise bout 2 (average of last 5 minutes). |
| Heart rate | Measured continuously with chest-band device | End of 30 minute exercise bout 3 (average of last 5 minutes). |
| Heart rate variability | Measures of variability computed from the time, frequency, time-frequency, scale-invariant, entropy, and other nonlinear domains | End of 30 minute exercise bout 1 (average of last 5 minutes). |
| Heart rate variability | Measures of variability computed from the time, frequency, time-frequency, scale-invariant, entropy, and other nonlinear domains | End of 30 minute exercise bout 2 (average of last 5 minutes). |
| Heart rate variability | Measures of variability computed from the time, frequency, time-frequency, scale-invariant, entropy, and other nonlinear domains | End of 30 minute exercise bout 3 (average of last 5 minutes). |
| Thermal comfort scale | Thermal comfort assessed via a questionnaire using the ASHRAE 4-point scale ("1=comfortable to 4=very uncomfortable") | End of 30 minute exercise bout 1 (average of last 5 minutes). |
| Thermal comfort scale | Thermal comfort assessed via a questionnaire using the ASHRAE 4-point scale ("1=comfortable to 4=very uncomfortable") | End of 30 minute exercise bout 2 (average of last 5 minutes). |
| Thermal comfort scale | Thermal comfort assessed via a questionnaire using the ASHRAE 4-point scale ("1=comfortable to 4=very uncomfortable") | End of 30 minute exercise bout 3 (average of last 5 minutes). |
| Thermal sensation scale | Thermal sensation will be assessed using the ASHRAE 7-point scale ("0=neutral to 7=extremely hot") | End of 30 minute exercise bout 1 (average of last 5 minutes). |
| Thermal sensation scale | Thermal sensation will be assessed using the ASHRAE 7-point scale ("0=neutral to 7=extremely hot") | End of 30 minute exercise bout 2 (average of last 5 minutes). |
| Thermal sensation scale | Thermal sensation will be assessed using the ASHRAE 7-point scale ("0=neutral to 7=extremely hot") | End of 30 minute exercise bout 3 (average of last 5 minutes). |
| Thirst sensation scale | Thirst sensation will be quantified using a 9-point scale ("1=not thirsty at all to 9=very, very thirsty") | End of 30 minute exercise bout 1 (average of last 5 minutes). |
| Thirst sensation scale | Thirst sensation will be quantified using a 9-point scale ("1=not thirsty at all to 9=very, very thirsty") | End of 30 minute exercise bout 2 (average of last 5 minutes). |
| Thirst sensation scale | Thirst sensation will be quantified using a 9-point scale ("1=not thirsty at all to 9=very, very thirsty") | End of 30 minute exercise bout 3 (average of last 5 minutes). |
| Rating of perceived exertion | Rating of perceived exertion will be quantified using a 14-point scale ("6=no exertion at all to 20=maximal exertion") | End of 30 minute exercise bout 1 (average of last 5 minutes). |
| Rating of perceived exertion | Rating of perceived exertion will be quantified using a 14-point scale ("6=no exertion at all to 20=maximal exertion") | End of 30 minute exercise bout 2 (average of last 5 minutes). |
| Rating of perceived exertion | Rating of perceived exertion will be quantified using a 14-point scale ("6=no exertion at all to 20=maximal exertion") | End of 30 minute exercise bout 3 (average of last 5 minutes). |