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The goal of this food intervention study is to screen/validate the whole grain food intake biomarker in health Chinese's population.
Although increased consumption of whole grains (WGs) is associated with improved health outcomes, the dietary intake assessment and health mechanisms for WGs or WG-containing food remain unresolved. In addition, information regarding its consumption and health effects in Chinese people is scarce. Biomarkers of WGs intake would allow a more accurate assessment of its consumption in nutrition studies. The investigators want to perform a crossover study where participants were subjected to a WG-wheat flour or a refine wheat-flour Chinese diet. Using a metabolomics approach, the investigators aimed to identify the WG-specific metabolites present in plasma/urine after consumption WG or WG foods, including new candidate biomarkers of WG intake.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| whole grain-wheat flour food, then refined wheat flour food | Experimental | Participants first received food made by 50 g whole grain wheat flour during breakfast in a fasting state. Standardized meals were provided to the volunteers from the dinner of the day before the intervention day, as well as up to 48 h after the administration of the test food. After a washout period of 5 days, volunteers followed a 2-day restricted diet before the intervention day. Participants then received food made by 50 g refined grain wheat flour in a fasting state. |
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| refined wheat flour food, then whole grain-wheat flour food | Experimental | Participants first received food made by 50 g refined grain wheat flour during breakfast in a fasting state. Standardized meals were provided to the volunteers from the dinner of the day before the intervention day, as well as up to 48 h after the administration of the test food. After a washout period of 5 days, volunteers followed a 2-day restricted diet before the intervention day. Participants then received food made by 50 g whole grain wheat flour in a fasting state. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| whole grain-wheat flour food+standardized meals | Other | whole grain food made by 50 g whole grain wheat flour |
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| Measure | Description | Time Frame |
|---|---|---|
| Changes in metabolite profiles present in blood plasma and urine before the dietary intervention and in kinetics over 24 hours. | Metabolite profiles analyzed using a non-targeted metabolomics approach and targeted metabolomics approach with a Orbitrap Mass Analyzer. Blood plasma samples collected at time 0 hours, 2 hours, 4 hours, and 24 hours. Urine fractions collected at 0-2 hours, 2-4 hours, 4-6 hours, 6-9 hours, 9-12 hours, 12-24 hours and 24-48 hours. Identification of biomarkers of acute intake of the foods of interest through the comparison of specific metabolomes after single dose of WG food or refined grain food in Chinese population. | Baseline and 0-24 hours after intervention food intake |
| Measure | Description | Time Frame |
|---|---|---|
| The influence of gut flora on whole grain markers | Gut flora abundance and metabolites level correlation analysis | after the administration of the test meal |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yunjia yang | Peking University | Principal Investigator |
| Yalin Zhou | Peking University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Nutrition and Food Hygiene, School of Public Health, Peking University | Beijing | China |
Shared IPD that underlie results in a publication
December 30, 2023
In a publication
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Randomized Crossover Assignment
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| refined wheat flour food+standardized meals | Other | refined grain food made by 50 g refined wheat flour |
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