The human body gets exposure to pesticides either directly or indirectly. By using pesticides on crops, humans come in direct contact with them and they affect the heaith

Immune system is the first defense line against pathogenic organisms; however, it is altered by the vulnerable environmental factors such as pesticides, which can cause structural or functional alterations in humoral or cell mechanisms (nonspecific or adaptive) of the immune response which lead to an increase in the susceptibility to infections

Inclusion Criteria:

1. pesticide applicators
2. Age ;20-60 years
3. Exposure to pesticides for more than 3 months

Exclusion Criteria:

• Subjects have recent severe trauma or surgery or recent infections