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| Name | Class |
|---|---|
| Dongguan Maternal and Children Health Hospital | OTHER |
| Foshan Women's and Children's Hospital | OTHER |
| BoAi Hospital of Zhongshan | OTHER |
| Children's Hospital of Chongqing Medical University |
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Many RCT(randomized controlled trial) studies reported that tranexamic acid reduced blood loss in women who had elective cesareans. However, most of these elective cesareans are without high-risk factors of postpartum hemorrhage, such as placenta previa. The prophylactic use of tranexamic acid in the placenta previa is not clear.
studies had poor quality and lacked adequate power to assess severe adverse events.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| study group | Experimental | Intravenous administration of 10 mL (1 g of tranexamic acid) diluted in 40 ml of normal saline, over 10 minutes after umbilical-cord clamping, the routine prophylactic uterotonic administration |
|
| control group | Placebo Comparator | Intravenous administration of 10 mL placebo (0.9% sodium chloride), diluted in 40 ml of normal saline, over 10 minutes after umbilical-cord clamping, the routine prophylactic uterotonic administration |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tranexamic acid | Drug | Intravenous administration of 10 mL (1 g of tranexamic acid), diluted in 40 ml of normal saline, over 10 minutes after umbilical-cord clamping, the routine prophylactic uterotonic administration |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of PPH | defined by a calculated estimated blood loss > 1000 mL [Calculated estimated blood loss = estimated blood volume × (preoperative hematocrit - postoperative hematocrit)/preoperative hematocrit (where estimated blood volume (mL) = weight (Kg) × 85)] or red blood cell (RBC) transfusion before day 2 postpartum . | Day 2 |
| Measure | Description | Time Frame |
|---|---|---|
| mean total calculated blood loss | Calculated estimated blood loss = estimated blood volume × (preoperative hematocrit - postoperative hematocrit)/preoperative hematocrit (where estimated blood volume (mL) = weight (Kg) × 85)] or red blood cell (RBC) transfusion before day 2 postpartum | Day 2 |
| mean gravimetrically estimated blood loss |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University | Guangzhou | Guangdong | 510150 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42128454 | Derived | Zhang L, Bi S, Chen L, Du L, He F, Qiao Y, Li Z, Zeng W, Zhao X, Chen X, Li X, Ding G, Zhou W, Sun B, Guo Q, Guo X, Jin F, Wang X, Zhu Q, Sun Q, Jiang S, Wang X, Cai F, Jiang Y, Gao J, Wang Z, Wang Z, Zhang L, Liu JM, Huang L, Yu L, Chen J, Zhang S, Poon LC, Li HT, Chen D; study's collaborator group. Prophylactic tranexamic acid for the prevention of postpartum haemorrhage in women with placenta praevia: multicentre, double blind, randomised, placebo controlled, phase 3 trial. BMJ. 2026 May 13;393:e089636. doi: 10.1136/bmj-2026-089636. | |
| 41624591 |
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| OTHER |
| Tianjin Central Hospital of Gynecology Obstetrics | OTHER |
| Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University | OTHER |
| Urumqi Maternal and Child Health Care Hospital | UNKNOWN |
| Zhuhai Women and Children's Hospital | UNKNOWN |
| The First Affiliated Hospital of Zhengzhou University | OTHER |
| Hunan Provincial Maternal and Child Health Care Hospital | OTHER |
| Dalian women and children's medical group | UNKNOWN |
| Nanfang Hospital, Southern Medical University | OTHER |
| Huadu District People's Hospital of Guangzhou | OTHER |
| Northwest Women's and Children's Hospital, Xi'an, Shaanxi | OTHER |
| First Affiliated Hospital, Sun Yat-Sen University | OTHER |
| Shenzhen Maternity & Child Healthcare Hospital | OTHER |
| Shenzhen Baoan Women's and Children's Hospital | UNKNOWN |
| Dongguan People's Hospital | OTHER_GOV |
| First Affiliated Hospital of Xinjiang Medical University | OTHER |
| Tongji Hospital | OTHER |
| Peking Union Medical College | OTHER |
| Second Affiliated Hospital of Guangzhou Medical University | OTHER |
| Fifth Affiliated Hospital of Guangzhou Medical University | OTHER |
| Shijiazhuang Obstetrics and Gynecology Hospital | OTHER |
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| 0.9% sodium chloride | Other | Intravenous administration of 10 mL placebo(0.9% sodium chloride), diluted in 40 ml of normal saline, over 10 minutes after umbilical-cord clamping, the routine prophylactic uterotonic administration |
|
estimated blood loss = (weight of materials used + materials not used - weight of all materials before surgery)/ 1.05 + volume included in the suction container |
| postpartum 24 hours |
| Number of Participants with additional uterotonic agents treatment | additional uterotonic agents include oxytocin, carbetocin, carboprost, misoprostol, ergonovine et al | baseline |
| incidence of postpartum transfusion | include RBC, plasma, platelet, cryo et al | baseline |
| incidence of postpartum iron perfusion | baseline |
| incidence of hypovolemic shock related to PPH | baseline |
| incidence of interventional therapy | include arterial embolization, abdominal aortic balloon, internal iliac artery/common iliac artery balloon et al | baseline |
| incidence of transfer to intensive care unit | baseline |
| Number of Participants with additional operations performed outside cesarean section | Additional operations include B-Lnych, uterine artery suture, partial hysterectomy, hysterectomy et al | baseline |
| incidence of maternal death from any cause | week 6 |
| incidence of hospital readmission | baseline |
| mean peripartum change in hemoglobin | the difference between the hemoglobin levels before delivery and at D2 | Day 2 |
| mean peripartum change in hematocrit levels | the difference between the hematocrit levels before delivery and at D2 | Day 2 |
| incidence of infectious complications | include endometritis, surgical-site infection, or pelvic abscess within 6 weeks post partum | week 6 |
| incidence of maternal thromboembolic events | including venous, arterial, or ischemic stroke or myocardial infarction within 6 weeks post partum | week 6 |
| Peking Union Medical College | Beijing | China |
| Peking University First Hospital | Beijing | China |
| Women and Children's Hospital of Chongqing Medical University | Chongqing | China |
| Dalian Women and Children's Medical Group | Dalian | China |
| Dongguan Maternal and Child Health Care Hospital | Dongguan | China |
| The Tenth Affiliated Hospital of Southern Medical University; Dongguan People's Hospital | Dongguan | China |
| Foshan Women and Children Hospital | Foshan | China |
| Boai Hospital of Zhongshan | Guangzhou | China |
| Huadu District People's Hospital of Guangzhou | Guangzhou | China |
| Nanfang Hospital, Southern Medical University, Guangzhou | Guangzhou | China |
| The Fifth Affiliated Hospital of Guangzhou Medical University | Guangzhou | China |
| The First Affiliated Hospital of Guangzhou Medical University | Guangzhou | China |
| The first Affiliated Hospital, Sun Yat-sen University | Guangzhou | China |
| The Second Affiliated Hospital of Guangzhou Medical University | Guangzhou | China |
| Zhuhai Women and Children's Hospital | Guangzhou | China |
| Obstetrics Department, the Maternal and Child Health Hospital of Hunan Province | Hunan | China |
| Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University | Jinan | China |
| Shenzhen Baoan Women's and Children's Hospital | Shenzhen | China |
| Shenzhen Maternal ＆ Child Healthcare Hospital Affiliated Southern Medical University | Shenzhen | China |
| Shijiazhuang Obstetrics and Gynecology Hospital | Shijiazhuang | China |
| Tianjin Central Hospital of Gynecology Obsterics | Tianjin | China |
| Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | Wuhan | China |
| Northwest Women's and Children's Hospital | Xi'an | China |
| First Affiliated Hospital of Xinjiang Medical University | Xinjiang | China |
| Urumqi Maternal and Child Health Care Hospital | Xinjiang | China |
| The First Affiliated Hospital of Zhengzhou University | Zhengzhou | China |
| Derived |
| Zhang L, Hu M, Bi S, Poon LC, He F, Li H, Zhang Y, Gu Z, Wang Z, Du L, Chen D; TRAPP Study Group. TRAPP- Protocol for Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Pregnant Women With Placenta Previa. Matern Fetal Med. 2026 Jan;8(1):3-12. doi: 10.1097/FM9.0000000000000297. Epub 2025 Jul 15. |
| ID | Term |
|---|---|
| D006473 | Postpartum Hemorrhage |
| D010923 | Placenta Previa |
| ID | Term |
|---|---|
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D011644 | Puerperal Disorders |
| D014592 | Uterine Hemorrhage |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010922 | Placenta Diseases |
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| ID | Term |
|---|---|
| D014148 | Tranexamic Acid |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D003509 | Cyclohexanecarboxylic Acids |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |
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