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ST-segment elevation myocardial infarction (STEMI) is an acute condition that accounts for 75% of sudden deaths in adults over 35 years of age and more than half of all cases of chronic heart failure. However, the mechanism of myocardial infarction remains poorly understood. At present, there is no national information system for myocardial infarction, as there is for other diseases such as multiple sclerosis (OFSEP cohort).
The purpose of this cohort is to enable studies and research projects to be carried out on the descriptive epidemiology of myocardial infarction, monitoring of patients undergoing treatment (safety, efficacy), quality of life and functional consequences of infarction, and research into new biological and imaging prognostic biomarkers. Its general objective is to provide researchers, hospital practitioners, medical interns, academics or industrialists with a quality epidemiological tool for research.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cohort group | Other | patient with ST-segment elevation myocardial infarction. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MRI | Other | 1 MRI at 1 month with gadolinium injection |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Research of potential new markers | Biomarkers assays (prognosis and diagnosis) between inclusion and one-year follow-up (H0, H4, H24, H48, M1, M12 since emergency revascularisation) | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Calculation of infarct size on MRI | Measurement of reperfusion lesions on MRI (mass in grams) | 1 month |
| Pharmacoepidemiology of myocardial infarction. | Description and evolution of patients' medical treatment between hospital discharge and 5 years follow-up. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Thomas BOCHATON, Dr | Contact | 04 72 35 75 41 | +33 | thomas.bochaton@chu-lyon.fr |
| Yvonne VARILLON | Contact | 04 72 35 69 64 | +33 | yvonne.varillon@chu-lyon.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospices Civils de Lyon - Hôpital Louis Pradel | Recruiting | Bron | Rhone | 69500 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39579225 | Derived | Stevic N, Pinede A, Mewton N, Ovize M, Argaud L, Lecour S, Boiteux C, Bochaton T, Cour M. Effect of ventricular fibrillation on infarct size after myocardial infarction: a translational study. Basic Res Cardiol. 2024 Dec;119(6):911-921. doi: 10.1007/s00395-024-01091-9. Epub 2024 Nov 23. |
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| ID | Term |
|---|---|
| D009203 | Myocardial Infarction |
| D000072657 | ST Elevation Myocardial Infarction |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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| Biocollection |
| Biological |
Biocollection from blood (H0, H4, H24, H48, 1 month, 1 year), urine (H48) and faecal (initial hospitalisation) samples. |
|
| Quality of life questionaries | Behavioral | EQ-5D-5L and HAD questionaries at 1 month and 1 year. |
|
| 5 years |
| Events between inclusion and 5 years follow-up | Time to a major adverse cardiovascular event | 5 years |
| Hospices Civils de Lyon - Hôpital de la Croix Rousse | Recruiting | Lyon | Rhone | 69004 | France |
|
| D007238 |
| Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |