Dairy Lipids and Cardiometabolic Risk

Bioactive Dairy Lipids to Manage Cardiometabolic Risk in Obesity

It is a randomized parallel arm intervention study in adults with severe obesity. The objective is to demonstrate that within a dietary handling for weight loss, the daily ingestion during 3 months of whole dairy products enriched with milk polar lipids or whole dairy products decreases to a greater extent fasting plasma apolipoprotein B concentrations than the daily ingestion of low-fat dairy products (control group).

Metabolic parameters will be assessed before and after the 3-month intervention, both at fasting and in postprandial period after the consumption of standardized meals.

Inclusion Criteria:

• Men and women between 18-70 years
• Body Mass Index (BMI) between 35 and 60 kg/m2 inclusive
• Stable body weight (weight change +/- 5 % for 3 months prior to screening)
• Consumption of at least 1 serving/day of dairy products made from cow's milk
• Informed consent

Exclusion Criteria:

• History of bariatric or digestive surgery or disease interfering with main outcomes
• Drinking more than 3 glasses of alcohol per day (>30g/day)
• Pregnancy, parturiency or breastfeeding
• Food allergies or intolerance to dairy products
• Dietary restriction (vegetarian or lactovegetarian) or high protein diet
• Use of dietary supplements
• Treated with lipid lowering drugs (fibrates, statins, anti-PCSK9, ezetimibe, cholestyramine) within the last 6 weeks before study entry
• Treated with insulin, GLP-1 analogs, acarbose, corticoids, beta-blockers.
• Medications interfering with intestinal microbiota (beta-lactamines within 3 months before the study or laxatives)
• Smoking ≥ 5 cigarettes/day during the past 6 months.