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To test the impact of flavanol supplementation of cardiac and vascular function and subsequently on exercise capacity in elderly individuals
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Flavanol | Experimental | 500 mg of flavanols twice daily |
|
| Placebo | Placebo Comparator | nutrient matched control capsule |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Flavanol | Drug | Assessement, supplementation for 30 days with either Placebo or Flavanols, Re-assessment |
|
| Measure | Description | Time Frame |
|---|---|---|
| Exercise capacity | maximum power output during cardiopulmonary exercise testing | 30 days |
| peakVO2 | maximum oxygen uptake during cardiopulmonary exercise testing | 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| flow mediated vasodilation (FMD) | marker for vascular function | 30 days |
| Oxygen pulse | oxygen uptake per heart beat (VO2/HR) as measured during cardiopulmonary exercise testing |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Heinrich Heine University | Düsseldorf | North Rhine-Westphalia | 40225 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41143317 | Derived | Duse DA, Grone M, Ophoff N, Kramser N, Schweers H, Ottaviani J, Schroeter H, Quast C, Bonner F, Heiss C, Sansone R, Jung C, Kelm M, Erkens R. Cocoa flavanols alleviate early diastolic dysfunction by decreasing left atrial volume in a randomized double blinded trial in healthy older individuals. Food Funct. 2025 Nov 10;16(22):8836-8845. doi: 10.1039/d5fo02589c. |
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| Placebo | Drug | Assessement, supplementation placebo for 30 days with either Placebo or Flavanols, Re-assessment |
|
| 30 days |
| aortic stiffness | cardiac magnetic resonance assessment of aortic diameter, distensibility and flow | 30 days |
| diastolic strain | cardiac magnetic resonance (CMR) based assessment of left ventricular strain | 30 days |
| Left ventricular function | systolic ejection fraction calculated based on magnetic resonance volumetric assessment of left ventricle | 30 days |
| left atrial volume index (LAVi) | cardiac magnetic resonance based assessment of left atrial volume index | 30 days |
| brain natriuretic peptide (nt-proBNP) | blood chemistry, nt-proBNP measurement | 30 days |
| aortic pulse wave velocity (PWV) | cardiac magnetic resonance based assessment of pulse wave velocity in ascending and descending aorta | 30 days |
| diastolic strain rate (SR) | cardiac magnetic resonance (CMR) based assessment of left ventricular strain rate early and during atrial contraction | 30 days |